ID   MTEFE_ARATH             Reviewed;         445 AA.
AC   Q9C6A1; Q0WSD2; Q9C9D2;
DT   11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Transcription termination factor MTERF15, mitochondrial {ECO:0000305};
DE   AltName: Full=Mitochondrial transcription termination factor 15 {ECO:0000303|PubMed:23087700};
DE   Flags: Precursor;
GN   Name=MTERF15 {ECO:0000303|PubMed:23087700};
GN   OrderedLocusNames=At1g74120 {ECO:0000312|Araport:AT1G74120,
GN   ECO:0000312|EMBL:AEE35552.1};
GN   ORFNames=F2P9.1 {ECO:0000312|EMBL:AAG52507.1},
GN   F9E11.3 {ECO:0000312|EMBL:AAG51878.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 198-445.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=21464319; DOI=10.1073/pnas.1103442108;
RA   Babiychuk E., Vandepoele K., Wissing J., Garcia-Diaz M., De Rycke R.,
RA   Akbari H., Joubes J., Beeckman T., Jaensch L., Frentzen M.,
RA   Van Montagu M.C., Kushnir S.;
RT   "Plastid gene expression and plant development require a plastidic protein
RT   of the mitochondrial transcription termination factor family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:6674-6679(2011).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=23087700; DOI=10.3389/fpls.2012.00233;
RA   Kleine T.;
RT   "Arabidopsis thaliana mTERF proteins: evolution and functional
RT   classification.";
RL   Front. Plant Sci. 3:233-233(2012).
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25402171; DOI=10.1371/journal.pone.0112360;
RA   Hsu Y.W., Wang H.J., Hsieh M.H., Hsieh H.L., Jauh G.Y.;
RT   "Arabidopsis mTERF15 is required for mitochondrial nad2 intron 3 splicing
RT   and functional complex I activity.";
RL   PLoS ONE 9:E112360-E112360(2014).
CC   -!- FUNCTION: Transcription termination factor required for mitochondrial
CC       NAD2 intron 3 splicing and normal membrane respiratory chain Complex I
CC       activity. Essential for normal plant growth and development. Binds to
CC       RNA but not to double-stranded DNA. {ECO:0000269|PubMed:25402171}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21464319,
CC       ECO:0000269|PubMed:25402171}.
CC   -!- DISRUPTION PHENOTYPE: Severe growth and developmental retardation.
CC       Dwarf plants with small organs, altered organ structure and nonviable
CC       seeds. {ECO:0000269|PubMed:25402171}.
CC   -!- SIMILARITY: Belongs to the mTERF family. {ECO:0000305}.
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DR   EMBL; AC016662; AAG52507.1; -; Genomic_DNA.
DR   EMBL; AC079678; AAG51878.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35552.1; -; Genomic_DNA.
DR   EMBL; AK228001; BAE99966.1; -; mRNA.
DR   PIR; C96769; C96769.
DR   RefSeq; NP_565080.1; NM_106072.4.
DR   AlphaFoldDB; Q9C6A1; -.
DR   IntAct; Q9C6A1; 8.
DR   STRING; 3702.AT1G74120.1; -.
DR   PaxDb; Q9C6A1; -.
DR   PRIDE; Q9C6A1; -.
DR   ProteomicsDB; 250982; -.
DR   EnsemblPlants; AT1G74120.1; AT1G74120.1; AT1G74120.
DR   GeneID; 843752; -.
DR   Gramene; AT1G74120.1; AT1G74120.1; AT1G74120.
DR   KEGG; ath:AT1G74120; -.
DR   Araport; AT1G74120; -.
DR   TAIR; locus:2037338; AT1G74120.
DR   eggNOG; KOG1267; Eukaryota.
DR   HOGENOM; CLU_034145_6_0_1; -.
DR   InParanoid; Q9C6A1; -.
DR   OMA; LWKEPRV; -.
DR   OrthoDB; 766540at2759; -.
DR   PhylomeDB; Q9C6A1; -.
DR   PRO; PR:Q9C6A1; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C6A1; baseline and differential.
DR   GO; GO:0009507; C:chloroplast; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IDA:TAIR.
DR   GO; GO:0009658; P:chloroplast organization; IBA:GO_Central.
DR   GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0000394; P:RNA splicing, via endonucleolytic cleavage and ligation; IMP:TAIR.
DR   Gene3D; 1.25.70.10; -; 1.
DR   InterPro; IPR003690; MTERF.
DR   InterPro; IPR038538; MTERF_sf.
DR   PANTHER; PTHR13068; PTHR13068; 1.
DR   Pfam; PF02536; mTERF; 2.
DR   SMART; SM00733; Mterf; 5.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; RNA-binding; Transcription;
KW   Transcription regulation; Transcription termination; Transit peptide.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..445
FT                   /note="Transcription termination factor MTERF15,
FT                   mitochondrial"
FT                   /id="PRO_0000436202"
SQ   SEQUENCE   445 AA;  51031 MW;  A0E85AB73AA8DEB9 CRC64;
     MASKLKTFIN LRDYPITLFN QIRSLSSRIL TPINQSHYRK RILLANLLQR YGFPPSSLQH
     FLSRNNHLLN SDLVETEISL GILLSLKIPQ KSLVSLISDC PNVLRSEFLR KWRVPLSNCG
     KHGVVSSSAI KSVLEHSSRI GIGPDKFNEC VRVLKSLGFC DSTVSRILSS FPGVLLVNEI
     EIRRKIEFLV GIGIARDNIE RFFHVFPEVL GIGTETRLKP LLDEFMKMGF SKDDVKKEIA
     REPRVLGLEL GELPRCLELI NTLKCREVIR VSIISEGAFR AGFEVKLRVD CLCKYGLIRR
     DAFKVVWKEP RVILYEIEDI EKKIEFLTNR MGFHINCLAD VPEYLGVNLQ KQIVPRYNVI
     DYLKLKGGLG CDIGLKGLIK PSMKRFYNLY VMPYPECERI FGKRKENVRV NKRHPAGLWK
     LMKPPSNLTT KEDVQNMKSF IESLA