MTEFH_ARATH
ID MTEFH_ARATH Reviewed; 558 AA.
AC Q9M219;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Transcription termination factor MTEF18, mitochondrial {ECO:0000305};
DE AltName: Full=Mitochondrial transcription termination factor 18 {ECO:0000303|PubMed:23087700};
DE AltName: Full=Protein SUPPRESSOR OF HOT1-4 1 {ECO:0000303|PubMed:22942382};
DE Flags: Precursor;
GN Name=MTERF18 {ECO:0000303|PubMed:23087700};
GN Synonyms=SHOT1 {ECO:0000303|PubMed:22942382};
GN OrderedLocusNames=At3g60400 {ECO:0000312|Araport:AT3G60400};
GN ORFNames=T8B10_60 {ECO:0000312|EMBL:CAB81826.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=21464319; DOI=10.1073/pnas.1103442108;
RA Babiychuk E., Vandepoele K., Wissing J., Garcia-Diaz M., De Rycke R.,
RA Akbari H., Joubes J., Beeckman T., Jaensch L., Frentzen M.,
RA Van Montagu M.C., Kushnir S.;
RT "Plastid gene expression and plant development require a plastidic protein
RT of the mitochondrial transcription termination factor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:6674-6679(2011).
RN [4]
RP GENE FAMILY.
RX PubMed=23087700; DOI=10.3389/fpls.2012.00233;
RA Kleine T.;
RT "Arabidopsis thaliana mTERF proteins: evolution and functional
RT classification.";
RL Front. Plant Sci. 3:233-233(2012).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
RP GLY-105.
RX PubMed=22942382; DOI=10.1105/tpc.112.101006;
RA Kim M., Lee U., Small I., des Francs-Small C.C., Vierling E.;
RT "Mutations in an Arabidopsis mitochondrial transcription termination
RT factor-related protein enhance thermotolerance in the absence of the major
RT molecular chaperone HSP101.";
RL Plant Cell 24:3349-3365(2012).
CC -!- FUNCTION: Transcription termination factor involved in the regulation
CC of mitochondrial-encoded gene expression. Essential for normal plant
CC growth and development. {ECO:0000269|PubMed:22942382}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21464319,
CC ECO:0000269|PubMed:22942382}.
CC -!- DISRUPTION PHENOTYPE: Severe growth and developmental retardation.
CC Dwarf plants. {ECO:0000269|PubMed:22942382}.
CC -!- SIMILARITY: Belongs to the mTERF family. {ECO:0000305}.
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DR EMBL; AL138646; CAB81826.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80055.1; -; Genomic_DNA.
DR PIR; T47851; T47851.
DR RefSeq; NP_191599.1; NM_115904.3.
DR AlphaFoldDB; Q9M219; -.
DR IntAct; Q9M219; 1.
DR STRING; 3702.AT3G60400.1; -.
DR iPTMnet; Q9M219; -.
DR PaxDb; Q9M219; -.
DR PRIDE; Q9M219; -.
DR ProteomicsDB; 250810; -.
DR EnsemblPlants; AT3G60400.1; AT3G60400.1; AT3G60400.
DR GeneID; 825211; -.
DR Gramene; AT3G60400.1; AT3G60400.1; AT3G60400.
DR KEGG; ath:AT3G60400; -.
DR Araport; AT3G60400; -.
DR TAIR; locus:2103291; AT3G60400.
DR eggNOG; KOG1267; Eukaryota.
DR HOGENOM; CLU_021017_0_1_1; -.
DR InParanoid; Q9M219; -.
DR OMA; APKILNQ; -.
DR OrthoDB; 739064at2759; -.
DR PhylomeDB; Q9M219; -.
DR PRO; PR:Q9M219; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M219; baseline and differential.
DR GO; GO:0009507; C:chloroplast; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:InterPro.
DR GO; GO:0009658; P:chloroplast organization; IBA:GO_Central.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR GO; GO:0007005; P:mitochondrion organization; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.25.70.10; -; 2.
DR InterPro; IPR003690; MTERF.
DR InterPro; IPR038538; MTERF_sf.
DR PANTHER; PTHR13068; PTHR13068; 1.
DR Pfam; PF02536; mTERF; 2.
DR SMART; SM00733; Mterf; 5.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transcription; Transcription regulation;
KW Transcription termination; Transit peptide.
FT TRANSIT 1..58
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 59..558
FT /note="Transcription termination factor MTEF18,
FT mitochondrial"
FT /id="PRO_0000436203"
FT MUTAGEN 105
FT /note="G->D: In shot1-1; short hypocotyl when grown in the
FT dark."
FT /evidence="ECO:0000269|PubMed:22942382"
SQ SEQUENCE 558 AA; 64562 MW; 6D64E6511C663BCF CRC64;
MFMVRLKFAS ISHNFSTVAA KHRRVPSKYK SLAIGKAQQA ITDYLHTTRS LSYTHAEQIA
SNASVSIRNL ILKLDFSVPT FSKSLRKHLS YHPINEFEFF FESIGIDYSE VSEFLPEKKF
FFSEDRTVLD AAFALSGFGF PWNKLGKLYK EERLVFVQRP GEIESRLLKF KDIGFSTVAV
IGTCLAIPRT LCGGGELGSE IRCLFVKLKR LFDEFDSHHL FEENVDSWLA VSRKIRIFYD
LGCENEEMWE LMCRNKSLFL EYSEEALMNK AGYFCRFGVS KEDAALLILR NPAIMNFDLE
KPVISVTGML KHFGLRQDEV DAVAQKYPYV FGRNQLKNLP YVLRAIDLHE RIFDILKNGN
HHLLASYTLM DPDEDLEREY QEGLEELQNS RTKRHNIQKL DFLHEIGFGE NGITMKVLQH
VHGTAVELHD RFQILLNSGI IFSKICMLIR SAPKILNQKP HSIQDKLRFL CGEMGDSLDY
LEVFPAYLCF DLENRISPRF RFHKWLVEKG FSEKSYSIAS IVATSEKAFI ARLYGIHPAI
PKHWFERFSS RKTRDTVS
