ID   MTF1_KLULA              Reviewed;         335 AA.
AC   P87250;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Mitochondrial transcription factor 1;
DE            EC=2.1.1.-;
DE   AltName: Full=Mitochondrial transcription factor MTTFB;
GN   Name=MTF1; OrderedLocusNames=KLLA0B08283g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9196077;
RA   Carrodeguas J.A., Yun S., Shadel G.S., Clayton D.A., Bogenhagen D.F.;
RT   "Functional conservation of yeast mtTFB despite extensive sequence
RT   divergence.";
RL   Gene Expr. 6:219-230(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mitochondrial transcription factor that confers selective
CC       promoter recognition on the core subunit of the yeast mitochondrial RNA
CC       polymerase. Interacts with DNA in a non-specific manner (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. rRNA adenine N(6)-methyltransferase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01026}.
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DR   EMBL; U81620; AAC49739.1; -; Genomic_DNA.
DR   EMBL; CR382122; CAH02292.1; -; Genomic_DNA.
DR   RefSeq; XP_451899.1; XM_451899.1.
DR   AlphaFoldDB; P87250; -.
DR   SMR; P87250; -.
DR   STRING; 28985.XP_451899.1; -.
DR   PRIDE; P87250; -.
DR   EnsemblFungi; CAH02292; CAH02292; KLLA0_B08283g.
DR   GeneID; 2897078; -.
DR   KEGG; kla:KLLA0_B08283g; -.
DR   eggNOG; ENOG502QY7G; Eukaryota.
DR   HOGENOM; CLU_034228_0_0_1; -.
DR   InParanoid; P87250; -.
DR   OMA; CKLSVIA; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0034245; C:mitochondrial DNA-directed RNA polymerase complex; IEA:EnsemblFungi.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:EnsemblFungi.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:EnsemblFungi.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0034246; F:mitochondrial transcription factor activity; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IEA:EnsemblFungi.
DR   GO; GO:0006391; P:transcription initiation from mitochondrial promoter; IEA:EnsemblFungi.
DR   Gene3D; 1.10.8.100; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR001737; KsgA/Erm.
DR   InterPro; IPR016586; Mtf1.
DR   InterPro; IPR023165; rRNA_Ade_diMease-like_C.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11727; PTHR11727; 1.
DR   Pfam; PF00398; RrnaAD; 1.
DR   PIRSF; PIRSF011649; MtTFB; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51689; SAM_RNA_A_N6_MT; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Methyltransferase; Mitochondrion; Reference proteome;
KW   RNA-binding; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN           1..335
FT                   /note="Mitochondrial transcription factor 1"
FT                   /id="PRO_0000096617"
FT   BINDING         79
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01026"
SQ   SEQUENCE   335 AA;  39201 MW;  1E6EC6D7C6C3B791 CRC64;
     MTKSSFLKSV LPLANKIHTS YGSQFEKNPK VINQILDKLN LESYYKSESL QILDIYAGPL
     IQSVILNERL KPKKHVLLED RLKFVELYQA TLKDHPSMVN YNKNPYKWET FLEMTNEDRV
     LTPSMQKRDH IHNEFLIAAN LTNKKGEQLY VQYLQCIANQ NWMQRFGLVK MLVWIPQQTA
     RKLFAPFSNK DRNRLTLLSE LATNTKLVAT SENSVKKFLP DCIEKFDPVI IPSDNKSPDD
     LSLVEINPRD HSIDLDHWDF VTQKLMILKS KPVEEMIEIL GHGARDWFIS RLDPVLLKKK
     PYELTYLEID EIAKVFALWP FKPSLLVDFY DENED