MTF1_SACPA
ID MTF1_SACPA Reviewed; 341 AA.
AC Q9Y829;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Mitochondrial transcription factor 1;
DE EC=2.1.1.-;
DE AltName: Full=Mitochondrial transcription factor mtTFB;
GN Name=MTF1;
OS Saccharomyces paradoxus (Yeast) (Saccharomyces douglasii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=27291;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=4301-3A;
RA Stein T., Jan P.S., Hehl S., Lisowsky T.;
RT "Expression studies and promoter analysis of the nuclear gene for
RT mitochondrial transcription factor 1 (MTF1) in yeast.";
RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial transcription factor that confers selective
CC promoter recognition on the core subunit of the yeast mitochondrial RNA
CC polymerase. Interacts with DNA in a non-specific manner (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. rRNA adenine N(6)-methyltransferase family.
CC {ECO:0000255|PROSITE-ProRule:PRU01026}.
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DR EMBL; Y08739; CAA69994.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9Y829; -.
DR SMR; Q9Y829; -.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0034246; F:mitochondrial transcription factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006391; P:transcription initiation from mitochondrial promoter; IEA:InterPro.
DR Gene3D; 1.10.8.100; -; 1.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR001737; KsgA/Erm.
DR InterPro; IPR016586; Mtf1.
DR InterPro; IPR023165; rRNA_Ade_diMease-like_C.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11727; PTHR11727; 1.
DR Pfam; PF00398; RrnaAD; 1.
DR PIRSF; PIRSF011649; MtTFB; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR PROSITE; PS51689; SAM_RNA_A_N6_MT; 1.
PE 3: Inferred from homology;
KW DNA-binding; Methyltransferase; Mitochondrion; RNA-binding;
KW S-adenosyl-L-methionine; Transcription; Transcription regulation;
KW Transferase.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..341
FT /note="Mitochondrial transcription factor 1"
FT /id="PRO_0000096619"
FT BINDING 23
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01026"
FT BINDING 77
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01026"
FT BINDING 101
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01026"
FT BINDING 137
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01026"
SQ SEQUENCE 341 AA; 39690 MW; B5F7C61140CB64D9 CRC64;
MSIPIPGIKD ISKLKFFYGF KYLWNPTVYN RIFDKLDLTK TYKHPQELKV LDLYPGVGVQ
SAIFYNKYCP KQYSLIEKRS SLYKFLNAKF EESPLQILKK DPYDWSTYSS LIDEERIFVP
EVQPSDHIND KFLTVANVTG EGSEGLIMQW LSCIGNKNWL YRFGKVKMLL WMPSTTAKKL
LARPSTHARS KCSVVREAFT DTKLIAISDA NELKGFDSHC IEEWDPVIFS AADIWPTKGK
PIALVEMDPI DFDFDVDNWD YVTRHLMILK RTPLNTVMDS LGHGGQQYFN SRITDKDLIK
KCPIDLTNDE FIYLTKLFME WPFKPDILMD FVDMYQTEHS G
