ID   MTFA_ASPFC              Reviewed;         336 AA.
AC   B0YDH7;
DT   17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=C2H2 finger domain transcription factor mtfA {ECO:0000305};
GN   Name=mtfA {ECO:0000303|PubMed:24728192}; ORFNames=AFUB_095620;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804 {ECO:0000312|Proteomes:UP000001699};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND SUBCELLULAR LOCATION.
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=24728192; DOI=10.1128/ec.00075-14;
RA   Smith T.D., Calvo A.M.;
RT   "The mtfA transcription factor gene controls morphogenesis, gliotoxin
RT   production, and virulence in the opportunistic human pathogen Aspergillus
RT   fumigatus.";
RL   Eukaryot. Cell 13:766-775(2014).
CC   -!- FUNCTION: Transcription factor that controls morphogenesis and
CC       virulence. Acts as a positive regulator of gliotixin and protease
CC       production. {ECO:0000269|PubMed:24728192}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24728192}.
CC   -!- DISRUPTION PHENOTYPE: Leads to a reduction of protease activity and a
CC       decreased virulence in a G.mellonella infection model.
CC       {ECO:0000269|PubMed:24728192}.
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DR   EMBL; DS499602; EDP47711.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0YDH7; -.
DR   EnsemblFungi; EDP47711; EDP47711; AFUB_095620.
DR   VEuPathDB; FungiDB:AFUB_095620; -.
DR   HOGENOM; CLU_053582_0_0_1; -.
DR   PhylomeDB; B0YDH7; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   4: Predicted;
KW   Metal-binding; Nucleus; Repeat; Transcription; Transcription regulation;
KW   Virulence; Zinc; Zinc-finger.
FT   CHAIN           1..336
FT                   /note="C2H2 finger domain transcription factor mtfA"
FT                   /id="PRO_0000435647"
FT   ZN_FING         272..294
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         300..325
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..126
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   336 AA;  36076 MW;  63D6BF9A49DBF3E2 CRC64;
     MDVASLISPS ESDTVPTFRS RSIQNSSASH YKRLSEQSTG SYFSAVPTHT TSYSRTPQPP
     LSPPAEDQSK CSLPSISILL ENADGAAAHA AKRQRNSLST HRDSDPRPPY DSITPHAMPP
     TPPLRPGSGF HSNGHSPSTS SVSAASSSAL MKNTESYPQA PIGLPSPTDR SSISSQGSVQ
     HAASAPYASP APSVSSFSSP IEPSTPSTAA YYQRNPAPNT FQNPSPFPQT STASLPSPGH
     QQMISPVTPA WQHHHYFPPS SSTSYQQNHD RYICRTCHKA FSRPSSLRIH SHSHTGEKPF
     RCTHAGCGKA FSVRSNMKRH ERGCHTGRPV ATAMVQ