ID   MTFA_YERPS              Reviewed;         270 AA.
AC   Q66C05; Q9ZEX5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Protein MtfA {ECO:0000255|HAMAP-Rule:MF_01593};
DE   AltName: Full=Mlc titration factor A {ECO:0000255|HAMAP-Rule:MF_01593};
GN   Name=mtfA {ECO:0000255|HAMAP-Rule:MF_01593}; OrderedLocusNames=YPTB1611;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 117-270.
RC   STRAIN=IP32637 / Serotype I;
RX   PubMed=9988474; DOI=10.1046/j.1365-2958.1998.01124.x;
RA   Buchrieser C., Brosch R., Bach S., Guiyoule A., Carniel E.;
RT   "The high-pathogenicity island of Yersinia pseudotuberculosis can be
RT   inserted into any of the three chromosomal asn tRNA genes.";
RL   Mol. Microbiol. 30:965-978(1998).
CC   -!- FUNCTION: Involved in the regulation of ptsG expression by binding and
CC       inactivating Mlc. {ECO:0000255|HAMAP-Rule:MF_01593}.
CC   -!- SUBUNIT: Interacts with Mlc. {ECO:0000255|HAMAP-Rule:MF_01593}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01593}.
CC   -!- SIMILARITY: Belongs to the MtfA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01593}.
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DR   EMBL; BX936398; CAH20850.1; -; Genomic_DNA.
DR   EMBL; AJ009592; CAA08753.1; -; Genomic_DNA.
DR   RefSeq; WP_002211042.1; NZ_CP009712.1.
DR   AlphaFoldDB; Q66C05; -.
DR   SMR; Q66C05; -.
DR   MEROPS; M90.001; -.
DR   EnsemblBacteria; CAH20850; CAH20850; YPTB1611.
DR   GeneID; 66841955; -.
DR   KEGG; ypo:BZ17_893; -.
DR   KEGG; yps:YPTB1611; -.
DR   PATRIC; fig|273123.14.peg.950; -.
DR   OMA; EHSGEAW; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProt.
DR   CDD; cd20169; Peptidase_M90_mtfA; 1.
DR   Gene3D; 1.10.472.150; -; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   HAMAP; MF_01593; MtfA; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR010384; MtfA_fam.
DR   InterPro; IPR042252; MtfA_N.
DR   PANTHER; PTHR30164; PTHR30164; 1.
DR   Pfam; PF06167; Peptidase_M90; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           1..270
FT                   /note="Protein MtfA"
FT                   /id="PRO_0000316333"
FT   CONFLICT        190
FT                   /note="E -> K (in Ref. 2; CAA08753)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   270 AA;  30659 MW;  954F314F6E3F14CE CRC64;
     MIKWLWKANK PQAEMLAQWH EALNIPLLAP LNEPEQQRLV SVASQLLQQK RFIPLQGLIL
     TPLMQARLAL LFALPVMELG AKWLDGFHEV LIYPSPFIVA EDWQDDLGLV HSGQSVQSGQ
     SWEQGPIVLN WQDIQDSFDL SGFNLVIHEA AHKLDMRNGG HSNGVPPIAM RDVAVWEHDL
     HHAMDNIQDE IDMVGVEGAS MDAYAASNPA ECFAVLSEYF FSAPELLEGR FPAVYQHFCR
     FYRQDPLARL KRWENSLADN PPPENTHSHR