ID   MTFP1_DANRE             Reviewed;         165 AA.
AC   Q6PCS6;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Mitochondrial fission process protein 1;
DE   AltName: Full=Mitochondrial 18 kDa protein;
DE            Short=MTP18;
GN   Name=mtfp1; Synonyms=mtp18; ORFNames=zgc:63910;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the mitochondrial division probably by regulating
CC       membrane fission. Loss-of-function leads to apoptosis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MTFP1 family. {ECO:0000305}.
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DR   EMBL; BC059182; AAH59182.1; -; mRNA.
DR   RefSeq; NP_956980.1; NM_200686.1.
DR   AlphaFoldDB; Q6PCS6; -.
DR   GeneID; 393659; -.
DR   KEGG; dre:393659; -.
DR   CTD; 51537; -.
DR   ZFIN; ZDB-GENE-040426-1293; mtfp1.
DR   InParanoid; Q6PCS6; -.
DR   OrthoDB; 1477184at2759; -.
DR   PhylomeDB; Q6PCS6; -.
DR   PRO; PR:Q6PCS6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR   InterPro; IPR019560; Mitochondrial_18_kDa_protein.
DR   PANTHER; PTHR11001; PTHR11001; 1.
DR   Pfam; PF10558; MTP18; 2.
PE   2: Evidence at transcript level;
KW   Apoptosis; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..165
FT                   /note="Mitochondrial fission process protein 1"
FT                   /id="PRO_0000212413"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   165 AA;  17984 MW;  8AF5E30E42547937 CRC64;
     MEPSADTHSK PVDIYRDTWV RFLGYANEVG EAFRALVPVG AVWASYGVAT TYVTADAIDK
     GRKAAAAHGE RPGKAVCVCV AVVDTFVWQA LASVAVPGFT INRVCAASHF LLSRTTRWPL
     PVRKWTTTAI GLSTIPFIIT PIDRSVDLLL DSSLRKLYSE GEKED