MTFP1_MOUSE
ID MTFP1_MOUSE Reviewed; 166 AA.
AC Q9CRB8; Q9CZX4;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Mitochondrial fission process protein 1;
DE AltName: Full=Mitochondrial 18 kDa protein;
DE Short=MTP18;
GN Name=Mtfp1; Synonyms=Mtp18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Liver, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 63-73, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-123, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: Involved in the mitochondrial division probably by regulating
CC membrane fission. Loss-of-function leads to apoptosis (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MTFP1 family. {ECO:0000305}.
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DR EMBL; AK006148; BAB24432.1; -; mRNA.
DR EMBL; AK010971; BAB27300.1; -; mRNA.
DR EMBL; AK012058; BAB27999.1; -; mRNA.
DR EMBL; AK078381; BAC37244.1; -; mRNA.
DR EMBL; BC058737; AAH58737.1; -; mRNA.
DR CCDS; CCDS24376.1; -.
DR RefSeq; NP_080719.2; NM_026443.4.
DR AlphaFoldDB; Q9CRB8; -.
DR BioGRID; 212524; 1.
DR IntAct; Q9CRB8; 1.
DR STRING; 10090.ENSMUSP00000004868; -.
DR PhosphoSitePlus; Q9CRB8; -.
DR SwissPalm; Q9CRB8; -.
DR jPOST; Q9CRB8; -.
DR MaxQB; Q9CRB8; -.
DR PaxDb; Q9CRB8; -.
DR PRIDE; Q9CRB8; -.
DR ProteomicsDB; 291433; -.
DR Antibodypedia; 34826; 110 antibodies from 21 providers.
DR DNASU; 67900; -.
DR Ensembl; ENSMUST00000004868; ENSMUSP00000004868; ENSMUSG00000004748.
DR GeneID; 67900; -.
DR KEGG; mmu:67900; -.
DR UCSC; uc007hug.1; mouse.
DR CTD; 51537; -.
DR MGI; MGI:1916686; Mtfp1.
DR VEuPathDB; HostDB:ENSMUSG00000004748; -.
DR eggNOG; KOG3945; Eukaryota.
DR GeneTree; ENSGT00390000004019; -.
DR HOGENOM; CLU_053720_1_0_1; -.
DR InParanoid; Q9CRB8; -.
DR OMA; DVFTWQM; -.
DR OrthoDB; 1477184at2759; -.
DR PhylomeDB; Q9CRB8; -.
DR TreeFam; TF324605; -.
DR BioGRID-ORCS; 67900; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Mtfp1; mouse.
DR PRO; PR:Q9CRB8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9CRB8; protein.
DR Bgee; ENSMUSG00000004748; Expressed in interventricular septum and 227 other tissues.
DR Genevisible; Q9CRB8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0006915; P:apoptotic process; IMP:MGI.
DR GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR GO; GO:0007006; P:mitochondrial membrane organization; ISA:MGI.
DR GO; GO:0007005; P:mitochondrion organization; IMP:MGI.
DR GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR InterPro; IPR019560; Mitochondrial_18_kDa_protein.
DR PANTHER; PTHR11001; PTHR11001; 1.
DR Pfam; PF10558; MTP18; 2.
PE 1: Evidence at protein level;
KW Apoptosis; Direct protein sequencing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..166
FT /note="Mitochondrial fission process protein 1"
FT /id="PRO_0000212412"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 123
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 152
FT /note="S -> N (in Ref. 1; BAB27999)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 166 AA; 18314 MW; 05B2A63491EE597E CRC64;
MSEQQRQGAE RDLYRDTWVR YLGYANEVGE AFRSLVPAAV VWLSYGVSSS YVLADAIDKG
KKAGEVPSPE AGRNTRMALA VVDTFVWQSL ASVAIPGFTI NRLCAASLYV LGTMTHWPPT
VRKWTTTTLG LLAIPVIIHP IDRSVDFLLD SSLRKLYPSV EKPSTP
