MTFR1_DANRE
ID MTFR1_DANRE Reviewed; 318 AA.
AC F1RCE7; B5RHZ5; F1R397; Q5PQY8;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Mitochondrial fission regulator 1;
DE Flags: Precursor;
GN Name=mtfr1; ORFNames=zgc:92267;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in mitochondrial aerobic respiration. May
CC also regulate mitochondrial organization and fission (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F1RCE7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F1RCE7-2; Sequence=VSP_043776, VSP_043777;
CC -!- SIMILARITY: Belongs to the MTFR1 family. {ECO:0000305}.
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DR EMBL; CU019631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC086966; AAH86966.1; -; mRNA.
DR EMBL; BC169195; AAI69195.1; -; mRNA.
DR RefSeq; NP_001008578.1; NM_001008578.1.
DR AlphaFoldDB; F1RCE7; -.
DR STRING; 7955.ENSDARP00000108672; -.
DR Ensembl; ENSDART00000066628; ENSDARP00000066627; ENSDARG00000045304. [F1RCE7-1]
DR Ensembl; ENSDART00000144574; ENSDARP00000116269; ENSDARG00000045304. [F1RCE7-2]
DR GeneID; 494035; -.
DR KEGG; dre:494035; -.
DR CTD; 9650; -.
DR ZFIN; ZDB-GENE-041212-86; mtfr1.
DR eggNOG; ENOG502QSSN; Eukaryota.
DR GeneTree; ENSGT00950000183215; -.
DR HOGENOM; CLU_117246_0_0_1; -.
DR InParanoid; F1RCE7; -.
DR OMA; KKPEIPN; -.
DR OrthoDB; 1485791at2759; -.
DR TreeFam; TF331404; -.
DR PRO; PR:F1RCE7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 24.
DR Bgee; ENSDARG00000045304; Expressed in mature ovarian follicle and 25 other tissues.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; ISS:UniProtKB.
DR GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR InterPro; IPR007972; Mtfr1.
DR PANTHER; PTHR14215; PTHR14215; 1.
DR Pfam; PF05308; Mito_fiss_reg; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..318
FT /note="Mitochondrial fission regulator 1"
FT /id="PRO_0000417557"
FT REGION 101..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..296
FT /note="Necessary and sufficient to promote mitochondrial
FT fission"
FT /evidence="ECO:0000250"
FT COILED 124..157
FT /evidence="ECO:0000255"
FT COMPBIAS 164..191
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 162
FT /note="A -> G (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_043776"
FT VAR_SEQ 163..318
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_043777"
FT CONFLICT 17
FT /note="S -> P (in Ref. 2; AAH86966/AAI69195)"
FT /evidence="ECO:0000305"
FT CONFLICT 20
FT /note="H -> D (in Ref. 2; AAH86966/AAI69195)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="F -> S (in Ref. 2; AAH86966)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 35169 MW; 1D5B814A75D6ACCB CRC64;
MSRNHRRIEM DLAVGSSSKH YGSSRSIVRR IATNLPLAPC PRVHFQLHPF ASGASFLNSP
NGPNVATLAD VAWIDREESD GPGRIRCEAD SGLVFRTQER RPLRRQRSLP SLHQVEPAQQ
SQTVINDEAI QKISVLETEL AKLRAQIAQI VQAQEQSAQS TAPAPGGPPV PPPMVPVPPP
PPPPPPCPTP SMQRSYSAID LIRERRGKKA EQNTVLDSAP KKPELPNMLD VLKDMGKVKL
RSVKSHQEDG NVKAKPVEPT DAAAMIAEAL KRKFAHRYRN DSECDGTFTF TAFENKPHVE
TPLFGQHMLK STGRRKMH
