ID   MTFR1_RAT               Reviewed;         335 AA.
AC   G3V9A7; A3F823;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Mitochondrial fission regulator 1;
DE   Flags: Precursor;
GN   Name=Mtfr1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New England Deaconess Hospital;
RA   Hagemann C., Stojic J., Weigelin B., Gerngras S., Roosen K., Vince G.H.;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in mitochondrial aerobic respiration. May
CC       also regulate mitochondrial organization and fission (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Note=May be
CC       associated with the inner and the outer mitochondrial membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MTFR1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EF221637; ABN11176.1; -; mRNA.
DR   EMBL; CH473961; EDM01060.1; -; Genomic_DNA.
DR   EMBL; CH473961; EDM01061.1; -; Genomic_DNA.
DR   RefSeq; NP_001094447.1; NM_001100977.1.
DR   RefSeq; XP_006232240.1; XM_006232178.2.
DR   RefSeq; XP_006232241.1; XM_006232179.3.
DR   RefSeq; XP_017446436.1; XM_017590947.1.
DR   AlphaFoldDB; G3V9A7; -.
DR   SMR; G3V9A7; -.
DR   STRING; 10116.ENSRNOP00000040894; -.
DR   CarbonylDB; G3V9A7; -.
DR   iPTMnet; G3V9A7; -.
DR   PhosphoSitePlus; G3V9A7; -.
DR   PaxDb; G3V9A7; -.
DR   Ensembl; ENSRNOT00000045586; ENSRNOP00000040894; ENSRNOG00000021359.
DR   GeneID; 311403; -.
DR   KEGG; rno:311403; -.
DR   CTD; 9650; -.
DR   RGD; 1304936; Mtfr1.
DR   eggNOG; ENOG502QSSN; Eukaryota.
DR   GeneTree; ENSGT00950000183215; -.
DR   HOGENOM; CLU_059135_0_0_1; -.
DR   InParanoid; G3V9A7; -.
DR   OMA; KKPEIPN; -.
DR   OrthoDB; 1485791at2759; -.
DR   TreeFam; TF331404; -.
DR   PRO; PR:G3V9A7; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Proteomes; UP000234681; Chromosome 2.
DR   Bgee; ENSRNOG00000021359; Expressed in testis and 18 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0009060; P:aerobic respiration; ISS:UniProtKB.
DR   GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   InterPro; IPR007972; Mtfr1.
DR   PANTHER; PTHR14215; PTHR14215; 1.
DR   Pfam; PF05308; Mito_fiss_reg; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Mitochondrion; Phosphoprotein; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..48
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           49..335
FT                   /note="Mitochondrial fission regulator 1"
FT                   /id="PRO_0000417555"
FT   REGION          94..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          168..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..306
FT                   /note="Necessary and sufficient to promote mitochondrial
FT                   fission"
FT                   /evidence="ECO:0000250"
FT   REGION          286..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          131..167
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        117..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..201
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..304
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         119
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15390"
FT   MOD_RES         129
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99MB2"
FT   CONFLICT        183
FT                   /note="V -> VPP (in Ref. 1; ABN11176)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   335 AA;  36815 MW;  8A23E327A345283A CRC64;
     MLGWIKCLMR MWFQRVGVSM QSVLWSGKPY GSSRSIVRKI GTNLSLIQCP RVQFQLTSHA
     TEWSPTHPGE DVVATFADVG WVATDEGECS TRLRTEVRSK PPLENNPPCF EKPPSRHISL
     PNSSQDKPSP KTTLASEEAL QKISALENEL AALRAQIAKI VTLQEQQSPS AGCLDSSTPV
     IVVPPPPPPP PPPPPLPPPP LVLHPSTSAL DLIKERREQR LSAGKTLAKG HPKKLDMPNM
     LEILKDMNSV KLRPVKRSEK DEKPRPVDIT DPAALIAEAL KKKFAYRHRH NSQGEAERGI
     PKPESDATSE PALFGPHTLK STGKMKALIE NVSDS