MTFR2_BOVIN
ID MTFR2_BOVIN Reviewed; 366 AA.
AC Q58CR1;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Mitochondrial fission regulator 2;
GN Name=MTFR2; Synonyms=FAM54A;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in mitochondrial aerobic respiration
CC essentially in the testis. Can also promote mitochondrial fission (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Note=Associated with
CC membranes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MTFR1 family. {ECO:0000305}.
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DR EMBL; BT021886; AAX46733.1; -; mRNA.
DR EMBL; DAAA02026730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02026731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC133562; AAI33563.1; -; mRNA.
DR RefSeq; NP_001017948.1; NM_001017948.3.
DR AlphaFoldDB; Q58CR1; -.
DR SMR; Q58CR1; -.
DR STRING; 9913.ENSBTAP00000010261; -.
DR PaxDb; Q58CR1; -.
DR PRIDE; Q58CR1; -.
DR Ensembl; ENSBTAT00000010261; ENSBTAP00000010261; ENSBTAG00000007799.
DR GeneID; 534254; -.
DR KEGG; bta:534254; -.
DR CTD; 113115; -.
DR VEuPathDB; HostDB:ENSBTAG00000007799; -.
DR VGNC; VGNC:31728; MTFR2.
DR eggNOG; ENOG502QUU8; Eukaryota.
DR GeneTree; ENSGT00950000183215; -.
DR HOGENOM; CLU_059135_0_0_1; -.
DR InParanoid; Q58CR1; -.
DR OMA; SHNHFVI; -.
DR OrthoDB; 1485791at2759; -.
DR TreeFam; TF331404; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000007799; Expressed in oocyte and 66 other tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central.
DR InterPro; IPR007972; Mtfr1.
DR PANTHER; PTHR14215; PTHR14215; 1.
DR Pfam; PF05308; Mito_fiss_reg; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Mitochondrion; Phosphoprotein; Reference proteome.
FT CHAIN 1..366
FT /note="Mitochondrial fission regulator 2"
FT /id="PRO_0000417558"
FT REGION 191..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 149..177
FT /evidence="ECO:0000255"
FT COMPBIAS 197..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..237
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 306
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P444"
FT MOD_RES 343
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P444"
SQ SEQUENCE 366 AA; 40979 MW; 5E65E9A764D4F6D6 CRC64;
MKKQCFFEFA SVFASSMSFI LSILREMLEY FGVPINQILH IWENKDYGSA RSIVRIIGKL
LPLEPCPRPN FELVPLLNSV DPANCGSVVP SFADVWCVAN DEEASYLRFR TWKNEEEEKI
ASFHPLQLFE GPLTPAVRRN KPRKNDWPES ETAIKKIAAL EDELAFLRSQ IAAIVGRQEL
GNSTKAGFLD LNGRPSGFGQ KPSSGATQLN VKQDSFSSSV RPSSPPPPSP PQISSVQPPC
SPLMKIASNS ICASDNSTTE VKQQHPDAGK TNYSHHSKNQ KNEAVPNMLD VLKDMNKVKL
RAIERSPGGR PIHKRKREDS PWDPVSLISH ALKQKFAFQE EDSFEKEDNC WESSPFSSPE
TSRVRL
