MTFR2_MOUSE
ID MTFR2_MOUSE Reviewed; 361 AA.
AC Q8VED8; E9PX02;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Mitochondrial fission regulator 2;
DE AltName: Full=DUF729 domain-containing protein 1;
GN Name=Mtfr2; Synonyms=Dufd1, Fam54a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP FUNCTION IN AEROBIC RESPIRATION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=20568109; DOI=10.1002/jcp.22279;
RA Monticone M., Panfoli I., Ravera S., Puglisi R., Jiang M.M., Morello R.,
RA Candiani S., Tonachini L., Biticchi R., Fabiano A., Cancedda R.,
RA Boitani C., Castagnola P.;
RT "The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and
RT cellular respiration.";
RL J. Cell. Physiol. 225:767-776(2010).
CC -!- FUNCTION: May play a role in mitochondrial aerobic respiration
CC essentially in the testis. Can also promote mitochondrial fission.
CC {ECO:0000269|PubMed:20568109}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20568109}.
CC Note=Associated with membranes.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in testis (at protein
CC level). Expressed to a lower extent in spleen.
CC {ECO:0000269|PubMed:20568109}.
CC -!- SIMILARITY: Belongs to the MTFR1 family. {ECO:0000305}.
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DR EMBL; AC153845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019132; AAH19132.1; -; mRNA.
DR CCDS; CCDS48511.1; -.
DR RefSeq; NP_082206.2; NM_027930.3.
DR AlphaFoldDB; Q8VED8; -.
DR SMR; Q8VED8; -.
DR BioGRID; 214941; 1.
DR IntAct; Q8VED8; 1.
DR STRING; 10090.ENSMUSP00000129315; -.
DR iPTMnet; Q8VED8; -.
DR PhosphoSitePlus; Q8VED8; -.
DR EPD; Q8VED8; -.
DR jPOST; Q8VED8; -.
DR MaxQB; Q8VED8; -.
DR PaxDb; Q8VED8; -.
DR PRIDE; Q8VED8; -.
DR ProteomicsDB; 287634; -.
DR Antibodypedia; 33003; 79 antibodies from 16 providers.
DR DNASU; 71804; -.
DR Ensembl; ENSMUST00000169712; ENSMUSP00000129315; ENSMUSG00000019992.
DR GeneID; 71804; -.
DR KEGG; mmu:71804; -.
DR UCSC; uc007eny.2; mouse.
DR CTD; 113115; -.
DR MGI; MGI:1919054; Mtfr2.
DR VEuPathDB; HostDB:ENSMUSG00000019992; -.
DR eggNOG; ENOG502QUU8; Eukaryota.
DR GeneTree; ENSGT00950000183215; -.
DR HOGENOM; CLU_059135_0_0_1; -.
DR InParanoid; Q8VED8; -.
DR OMA; SHNHFVI; -.
DR OrthoDB; 1485791at2759; -.
DR PhylomeDB; Q8VED8; -.
DR TreeFam; TF331404; -.
DR BioGRID-ORCS; 71804; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Mtfr2; mouse.
DR PRO; PR:Q8VED8; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8VED8; protein.
DR Bgee; ENSMUSG00000019992; Expressed in animal zygote and 82 other tissues.
DR ExpressionAtlas; Q8VED8; baseline and differential.
DR Genevisible; Q8VED8; MM.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; IMP:UniProtKB.
DR GO; GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
DR GO; GO:0007005; P:mitochondrion organization; IDA:UniProtKB.
DR InterPro; IPR007972; Mtfr1.
DR PANTHER; PTHR14215; PTHR14215; 1.
DR Pfam; PF05308; Mito_fiss_reg; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Phosphoprotein; Reference proteome.
FT CHAIN 1..361
FT /note="Mitochondrial fission regulator 2"
FT /id="PRO_0000087165"
FT REGION 191..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..237
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P444"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P444"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P444"
FT CONFLICT 67
FT /note="C -> F (in Ref. 2; AAH19132)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="D -> E (in Ref. 2; AAH19132)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="A -> V (in Ref. 2; AAH19132)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="P -> L (in Ref. 2; AAH19132)"
FT /evidence="ECO:0000305"
FT CONFLICT 228
FT /note="P -> L (in Ref. 2; AAH19132)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="L -> F (in Ref. 2; AAH19132)"
FT /evidence="ECO:0000305"
FT CONFLICT 297
FT /note="R -> K (in Ref. 2; AAH19132)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 361 AA; 40748 MW; D808B7FC26C73AFB CRC64;
MPRDGTNEQR FLELPSPMSF ILNILRNVLE YFGVPVDQDL LICQNKNCGS ARSIVRIIGR
RLPLKPCRRP HFELIPHVNS TESDDYELRV PSFADVLCVA NDEEASCLRF RHSLWQKKEE
RKIAPFYPSK LTWDPSSPGL RQNKTETDDL PVNEAAIKKI AALEDELTFL RSQIAAIVAM
QDLRESRETG FIDLSDEQVP PSSATTGLSV EPDHAPSVVL PPPPPPPPPP QFSLQPPSSL
PMQPGSANTH DIDSLATEME RQLSGVKKTD DSHHSKSQRL RDVPNMLDVL KDVNKVRLRP
VERSPGGRPV QKRKRRSSEW DPVSLISNAL KQKFAFQDDS FDRENSSWEC SPFSSPETSR
F
