ID   MTFR2_RAT               Reviewed;         373 AA.
AC   B0K035;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Mitochondrial fission regulator 2;
GN   Name=Mtfr2; Synonyms=Fam54a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in mitochondrial aerobic respiration
CC       essentially in the testis. Can also promote mitochondrial fission (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Note=Associated with
CC       membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MTFR1 family. {ECO:0000305}.
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DR   EMBL; BC159435; AAI59436.1; -; mRNA.
DR   RefSeq; NP_001277039.1; NM_001290110.1.
DR   AlphaFoldDB; B0K035; -.
DR   SMR; B0K035; -.
DR   STRING; 10116.ENSRNOP00000042360; -.
DR   PaxDb; B0K035; -.
DR   PRIDE; B0K035; -.
DR   Ensembl; ENSRNOT00000079069; ENSRNOP00000072258; ENSRNOG00000058050.
DR   GeneID; 100911069; -.
DR   KEGG; rno:100911069; -.
DR   CTD; 113115; -.
DR   RGD; 6494892; Mtfr2.
DR   eggNOG; ENOG502QZG7; Eukaryota.
DR   GeneTree; ENSGT00950000183163; -.
DR   HOGENOM; CLU_059135_0_0_1; -.
DR   InParanoid; B0K035; -.
DR   OrthoDB; 1485791at2759; -.
DR   PhylomeDB; B0K035; -.
DR   TreeFam; TF331404; -.
DR   PRO; PR:B0K035; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000058050; Expressed in thymus and 20 other tissues.
DR   ExpressionAtlas; B0K035; baseline and differential.
DR   Genevisible; B0K035; RN.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0009060; P:aerobic respiration; ISO:RGD.
DR   GO; GO:0000266; P:mitochondrial fission; ISO:RGD.
DR   GO; GO:0007005; P:mitochondrion organization; ISO:RGD.
DR   InterPro; IPR007972; Mtfr1.
DR   PANTHER; PTHR14215; PTHR14215; 1.
DR   Pfam; PF05308; Mito_fiss_reg; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Mitochondrion; Phosphoprotein; Reference proteome.
FT   CHAIN           1..373
FT                   /note="Mitochondrial fission regulator 2"
FT                   /id="PRO_0000417559"
FT   REGION          189..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          346..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          151..179
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        194..208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..251
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..285
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..317
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..373
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         136
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P444"
FT   MOD_RES         312
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P444"
FT   MOD_RES         348
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P444"
SQ   SEQUENCE   373 AA;  40772 MW;  B13AC43A21559EA4 CRC64;
     MQRDGTNEQC FLELASPMSF ILNILRNMLA YFGVPVDQDL LIFQNKDYGS ARSIVRVIGR
     MLPLEPCRRP RFELTPPANA KEVDDYELAV PSFADVLCVA DDGEAGCLRF RHSLWKKAEG
     KAALFHPSKL PWDLSSPALS QNRTVADDLP VSEAAIKKIA ALEDELTSLR AQIAAIVAMQ
     DLGGGGETGF ISLSDGPSME QVPPSSATAR LSVEPDHVPS VVLSPPPLPP PPPPLPPPQF
     SLQPPSSLPV PPGSANTRGI DNLAAEMKKR PSGVKKTDGS HHSESQRVSD VPNMLDVLKD
     MNKVKLRPVE RSPGGRPIQK RRRQSSQWDP VSLISNALKQ KFAFQDDSFD SENRSWQGSP
     FSSPETSRNG SRF