ID   MTG1_AEDAE              Reviewed;         316 AA.
AC   Q17EJ1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Mitochondrial GTPase 1 {ECO:0000250|UniProtKB:Q9BT17};
DE   Flags: Precursor;
GN   ORFNames=AAEL003813;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT44888.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Plays a role in the regulation of the mitochondrial ribosome
CC       assembly and of translational activity (By similarity). Displays
CC       mitochondrial GTPase activity (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BT17}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BT17}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9BT17}; Matrix side
CC       {ECO:0000250|UniProtKB:Q9BT17}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; CH477282; EAT44888.1; -; Genomic_DNA.
DR   RefSeq; XP_001664178.1; XM_001664128.1.
DR   AlphaFoldDB; Q17EJ1; -.
DR   SMR; Q17EJ1; -.
DR   STRING; 7159.AAEL003813-PA; -.
DR   PRIDE; Q17EJ1; -.
DR   VEuPathDB; VectorBase:AAEL023552; -.
DR   eggNOG; KOG2485; Eukaryota.
DR   HOGENOM; CLU_011106_0_2_1; -.
DR   InParanoid; Q17EJ1; -.
DR   OMA; GVLWPKF; -.
DR   OrthoDB; 583045at2759; -.
DR   PhylomeDB; Q17EJ1; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR016478; GTPase_MTG1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   PIRSF; PIRSF006230; MG442; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Nucleotide-binding; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BT17, ECO:0000255"
FT   CHAIN           ?..316
FT                   /note="Mitochondrial GTPase 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BT17"
FT                   /id="PRO_0000409877"
FT   DOMAIN          28..203
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   BINDING         73..76
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O31743"
FT   BINDING         147..152
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O31743"
FT   BINDING         199
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O31743"
SQ   SEQUENCE   316 AA;  35672 MW;  5E467759BF5B05B2 CRC64;
     MSNAFRTVFP TVNRELLNWF PGHMGKGMKQ MQQKLKQVDC VIEVHDARIP LSGRNSEFRY
     TISGVKPHIL VLNKKDKIDR RLQGRVVDRL QQEDSEARHI LFTNCKDQSC NGIRKVMPLA
     QDLILSSNRF NRADQKEYCI MIIGVPNVGK SSLINVLRNR HLNKKGASQV GAVAGITRSV
     LNKIKISEDP LVYLLDTPGI LKPNIADTET GLRLALVSCL QDHLVGEELI ADYLLYLLNK
     RGNFKYVELM GLKEPTDSIA EVLIAGSKHL DKTVRVRHYD GSFVIRPDAM LAARHMIKAF
     RTGAFGKILI DDDKFV