ID   MTG1_BOVIN              Reviewed;         332 AA.
AC   Q4PS77; Q3SZ06;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Mitochondrial ribosome-associated GTPase 1;
DE   AltName: Full=Mitochondrial GTPase 1;
DE   Flags: Precursor;
GN   Name=MTG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=17091316; DOI=10.1007/s00335-006-0078-7;
RA   Uboldi C., Paulis M., Guidi E., Bertoni A., Di Meo G.P., Perucatti A.,
RA   Iannuzzi L., Raimondi E., Brunner R.M., Eggen A., Ferretti L.;
RT   "Cloning of the bovine prion-like Shadoo (SPRN) gene by comparative
RT   analysis of the predicted genomic locus.";
RL   Mamm. Genome 17:1130-1139(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the regulation of the mitochondrial ribosome
CC       assembly and of translational activity (By similarity). Displays
CC       mitochondrial GTPase activity (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BT17}.
CC   -!- SUBUNIT: Associates with the mitochondrial ribosome large subunit; the
CC       association occurs in a GTP-dependent manner (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BT17}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BT17}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9BT17}; Matrix side
CC       {ECO:0000250|UniProtKB:Q9BT17}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ058604; AAY83879.1; -; Genomic_DNA.
DR   EMBL; DQ058609; AAY83883.1; -; mRNA.
DR   EMBL; BC103282; AAI03283.1; -; mRNA.
DR   RefSeq; NP_001020498.2; NM_001025327.2.
DR   AlphaFoldDB; Q4PS77; -.
DR   SMR; Q4PS77; -.
DR   STRING; 9913.ENSBTAP00000027058; -.
DR   PaxDb; Q4PS77; -.
DR   PRIDE; Q4PS77; -.
DR   GeneID; 509768; -.
DR   KEGG; bta:509768; -.
DR   CTD; 92170; -.
DR   eggNOG; KOG2485; Eukaryota.
DR   HOGENOM; CLU_011106_0_2_1; -.
DR   InParanoid; Q4PS77; -.
DR   OrthoDB; 583045at2759; -.
DR   TreeFam; TF314530; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0005761; C:mitochondrial ribosome; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; ISS:UniProtKB.
DR   GO; GO:0032543; P:mitochondrial translation; IBA:GO_Central.
DR   GO; GO:0070129; P:regulation of mitochondrial translation; ISS:UniProtKB.
DR   GO; GO:0044065; P:regulation of respiratory system process; ISS:UniProtKB.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR016478; GTPase_MTG1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   PIRSF; PIRSF006230; MG442; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Nucleotide-binding; Reference proteome; Transit peptide;
KW   Translation regulation.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..332
FT                   /note="Mitochondrial ribosome-associated GTPase 1"
FT                   /id="PRO_0000280261"
FT   DOMAIN          36..209
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   BINDING         83..86
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         153..158
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         205
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        59
FT                   /note="Q -> R (in Ref. 1; AAY83879/AAY83883)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   332 AA;  37004 MW;  8AEA59839AE371EF CRC64;
     MRLSPRSLCA AVRAAWRESF PLEGRDVARW FPGHMAKGLK KMQSSLRLVD CIIEVHDAQI
     PLSGRNPLFQ ETLGLKPHLL VLNKMDLADL KEQQKIIQHL EREGIKHVVF TNCVKDENVK
     QVIPTVTELV GSSYRYHRGE HVEYCIMVIG VPNVGKSSLI NSLRRQHLRK GKATRVGGEP
     GITRAVMSRI QVCERPLMFL LDTPGVLAPR IPSVETGLKL ALCGTVLDHL VGEETLADFL
     LYTLNRHQLS GYVQHYGLGE ACDDIASVLK RVAVKLRKTQ KVKVLTGTGN VNVIQPDYPA
     AARDFLRAFR SGLLGPVMLD RDLLQGRSAE ES