MTG1_DROPS
ID MTG1_DROPS Reviewed; 320 AA.
AC Q29AU5;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Mitochondrial GTPase 1 {ECO:0000250|UniProtKB:Q9BT17};
DE Flags: Precursor;
GN ORFNames=GA14342;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL27254.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Plays a role in the regulation of the mitochondrial ribosome
CC assembly and of translational activity (By similarity). Displays
CC mitochondrial GTPase activity (By similarity).
CC {ECO:0000250|UniProtKB:Q9BT17}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9BT17}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9BT17}; Matrix side
CC {ECO:0000250|UniProtKB:Q9BT17}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR EMBL; CM000070; EAL27254.2; -; Genomic_DNA.
DR RefSeq; XP_001358117.2; XM_001358080.3.
DR AlphaFoldDB; Q29AU5; -.
DR SMR; Q29AU5; -.
DR STRING; 7237.FBpp0283471; -.
DR EnsemblMetazoa; FBtr0285033; FBpp0283471; FBgn0074370.
DR GeneID; 4800930; -.
DR KEGG; dpo:Dpse_GA14342; -.
DR eggNOG; KOG2485; Eukaryota.
DR HOGENOM; CLU_011106_0_2_1; -.
DR InParanoid; Q29AU5; -.
DR OMA; GVLWPKF; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0074370; Expressed in male reproductive system and 3 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR016478; GTPase_MTG1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF006230; MG442; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 3: Inferred from homology;
KW GTP-binding; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Nucleotide-binding; Reference proteome; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q9BT17, ECO:0000255"
FT CHAIN ?..320
FT /note="Mitochondrial GTPase 1"
FT /evidence="ECO:0000250|UniProtKB:Q9BT17"
FT /id="PRO_0000409876"
FT DOMAIN 31..208
FT /note="CP-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT BINDING 78..81
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:O31743"
FT BINDING 152..157
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:O31743"
FT BINDING 204
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:O31743"
SQ SEQUENCE 320 AA; 36090 MW; A0DE2BD1603085E6 CRC64;
MTAQLNPFRN AFRLPTKQRI NWFPGHMNKG MRQIQQKLRN VDCIVEIHDS RIPLAGRNSQ
FFDTITGSGV KPHILVLNKV DLLGPKQQRS VLQQLRRQQP ELKNILFTNC KDQRNHGVLD
ILPLATQLVG DSSRYNRAQS AEHNIMIIGV PNVGKSSIIN VLRNVHLKKR SAARVGAEAG
VTRAVGERIK IQEKPAVYMI DTPGILQPSV TDDEMGMKLA LVGCLPDHIV GEDLIADYLL
YWLNKHRRYE YVEKLSLSSG PSDNISAVLA EYAQTHGMFH RVKQYDGQVE VMTNLLAAAR
KFIQFFRTGQ LGSINLDEHA
