MTG1_MOUSE
ID MTG1_MOUSE Reviewed; 326 AA.
AC Q8R2R6; Q3UMX2; Q3UN50;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Mitochondrial ribosome-associated GTPase 1;
DE AltName: Full=GTP-binding protein 7;
DE AltName: Full=Mitochondrial GTPase 1;
DE Flags: Precursor;
GN Name=Mtg1; Synonyms=Gm169, Gtpbp7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in the regulation of the mitochondrial ribosome
CC assembly and of translational activity (By similarity). Displays
CC mitochondrial GTPase activity (By similarity).
CC {ECO:0000250|UniProtKB:Q9BT17}.
CC -!- SUBUNIT: Associates with the mitochondrial ribosome large subunit; the
CC association occurs in a GTP-dependent manner (By similarity).
CC {ECO:0000250|UniProtKB:Q9BT17}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9BT17}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9BT17}; Matrix side
CC {ECO:0000250|UniProtKB:Q9BT17}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27306.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK144453; BAE25897.1; -; mRNA.
DR EMBL; AK144625; BAE25976.1; -; mRNA.
DR EMBL; BC027306; AAH27306.1; ALT_SEQ; mRNA.
DR CCDS; CCDS52432.1; -.
DR RefSeq; NP_955005.2; NM_199301.2.
DR AlphaFoldDB; Q8R2R6; -.
DR SMR; Q8R2R6; -.
DR BioGRID; 229331; 2.
DR STRING; 10090.ENSMUSP00000036491; -.
DR iPTMnet; Q8R2R6; -.
DR PhosphoSitePlus; Q8R2R6; -.
DR SwissPalm; Q8R2R6; -.
DR EPD; Q8R2R6; -.
DR MaxQB; Q8R2R6; -.
DR PaxDb; Q8R2R6; -.
DR PeptideAtlas; Q8R2R6; -.
DR PRIDE; Q8R2R6; -.
DR ProteomicsDB; 290214; -.
DR Antibodypedia; 32682; 111 antibodies from 21 providers.
DR DNASU; 212508; -.
DR Ensembl; ENSMUST00000036977; ENSMUSP00000036491; ENSMUSG00000039018.
DR GeneID; 212508; -.
DR KEGG; mmu:212508; -.
DR UCSC; uc009khd.2; mouse.
DR CTD; 92170; -.
DR MGI; MGI:2685015; Mtg1.
DR VEuPathDB; HostDB:ENSMUSG00000039018; -.
DR eggNOG; KOG2485; Eukaryota.
DR GeneTree; ENSGT00500000044923; -.
DR HOGENOM; CLU_011106_0_2_1; -.
DR InParanoid; Q8R2R6; -.
DR OMA; GVLWPKF; -.
DR OrthoDB; 583045at2759; -.
DR PhylomeDB; Q8R2R6; -.
DR TreeFam; TF314530; -.
DR BioGRID-ORCS; 212508; 20 hits in 74 CRISPR screens.
DR PRO; PR:Q8R2R6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8R2R6; protein.
DR Bgee; ENSMUSG00000039018; Expressed in interventricular septum and 250 other tissues.
DR ExpressionAtlas; Q8R2R6; baseline and differential.
DR Genevisible; Q8R2R6; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0005761; C:mitochondrial ribosome; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IBA:GO_Central.
DR GO; GO:0070129; P:regulation of mitochondrial translation; ISS:UniProtKB.
DR GO; GO:0044065; P:regulation of respiratory system process; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR016478; GTPase_MTG1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF006230; MG442; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Nucleotide-binding; Reference proteome; Transit peptide;
KW Translation regulation.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..326
FT /note="Mitochondrial ribosome-associated GTPase 1"
FT /id="PRO_0000280263"
FT DOMAIN 35..208
FT /note="CP-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT BINDING 82..85
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 152..157
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 204
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT CONFLICT 5
FT /note="P -> L (in Ref. 1; BAE25976)"
FT /evidence="ECO:0000305"
FT CONFLICT 316
FT /note="V -> M (in Ref. 2; AAH27306)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="M -> L (in Ref. 1; BAE25976)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 326 AA; 36679 MW; 6FF2DEDE01D23B94 CRC64;
MRLWPQAWGA VRGAWRECFP LQGHDVARWF PGHMAKGLKK MQSSLKSVDC VIEVHDARIP
FSGRNPLFQE LLGLKPHLLV LNKMDLADLT EQQKIVQRLE EKGLSNVLFT NCVKDENIKQ
IVPKVMELIR CSYRYHRAET PEYCIMVVGV PNVGKSSLIN SLRRQHLRTG KAARVGGEPG
ITRAVTSRIQ VCERPLVFLL DTPGVLAPRI ESVETGLKLA LCGTVLDHLV GEETMADYLL
YTLNRHGLFG YVQHYALASA CDQIEWVLKN VAIKLRKTRK VKVLTGTGNV NVIQPDYAMA
ARDFLRTFRS GLLGQVMLDR DIIPAC
