MTG1_SCHPO
ID MTG1_SCHPO Reviewed; 328 AA.
AC O74776;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Mitochondrial GTPase 1;
DE Flags: Precursor;
GN Name=mtg1; ORFNames=SPBC25B2.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Mitochondrial GTPase involved in assembly of the large
CC ribosomal subunit (By similarity). Plays a role in expression of the
CC mitochondrial translational machinery (By similarity).
CC {ECO:0000250|UniProtKB:Q03151}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q03151}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q03151}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR EMBL; CU329671; CAA21262.1; -; Genomic_DNA.
DR PIR; T39980; T39980.
DR RefSeq; NP_596072.1; NM_001021984.2.
DR AlphaFoldDB; O74776; -.
DR SMR; O74776; -.
DR BioGRID; 276970; 25.
DR STRING; 4896.SPBC25B2.04c.1; -.
DR MaxQB; O74776; -.
DR PaxDb; O74776; -.
DR EnsemblFungi; SPBC25B2.04c.1; SPBC25B2.04c.1:pep; SPBC25B2.04c.
DR GeneID; 2540442; -.
DR KEGG; spo:SPBC25B2.04c; -.
DR PomBase; SPBC25B2.04c; mtg1.
DR VEuPathDB; FungiDB:SPBC25B2.04c; -.
DR eggNOG; KOG2485; Eukaryota.
DR HOGENOM; CLU_011106_0_1_1; -.
DR InParanoid; O74776; -.
DR OMA; VYFVGMP; -.
DR PhylomeDB; O74776; -.
DR PRO; PR:O74776; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:PomBase.
DR GO; GO:0005759; C:mitochondrial matrix; IC:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; ISO:PomBase.
DR GO; GO:0032543; P:mitochondrial translation; ISO:PomBase.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR016478; GTPase_MTG1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF006230; MG442; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 3: Inferred from homology;
KW GTP-binding; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Nucleotide-binding; Reference proteome; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..328
FT /note="Mitochondrial GTPase 1"
FT /id="PRO_0000280264"
FT DOMAIN 23..211
FT /note="CP-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT BINDING 70..73
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 155..160
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 207
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 328 AA; 37871 MW; B1C21FEA0F74FE04 CRC64;
MAFVARQTFE YQMPSTWYPG HMNKTLKRLK NLTSSNDIFV EVRDARIPLT SRNYVMEDFL
NKKNRIIVYN KCDLADTFHT KAKVSKHRIQ NLAQQFQNVE CWFKETSTPE KSAFITPYVS
KAPYFAKELL RLIRTLVDQA SANGRVYVYF VGMPNTGKSS ILNSLRNVAL RKSKSAIVGN
YPGVTKRISE IVRLFNDMDV YMLDTPGIMT PSITKPEDML KLSLVGCVKE GIVHPVTVVD
YLLFHLNRID PSLYSKWSLP TNDVDEFLQN TAYKARKLTK GGFDENFVSN YVIQQYRIGR
LGRFQLDTID KNELLIRLHN EQNKKNAK
