MTH10_DROME
ID MTH10_DROME Reviewed; 585 AA.
AC Q9W0R5; Q7YWL1; Q86BK3; Q95NU7; Q95YN4;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Probable G-protein coupled receptor Mth-like 10;
DE AltName: Full=Protein methuselah-like 10;
DE Flags: Precursor;
GN Name=mthl10; Synonyms=mth2; ORFNames=CG17061;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-585.
RC STRAIN=CT97_1, CT97_3, CT97_4, HFL97_15, HFL97_16, HFL97_8, JFL97_1,
RC JFL97_5, JFL97_9, MA97_1, MA97_4, MA97_6, MFL97_1, VT97_1, ZIM(H)23,
RC ZIM(H)26, ZIM(H)39, ZIM(H)44, ZIM(S)15, ZIM(S)24, ZIM(S)35, ZIM(S)37, and
RC ZIM(S)49;
RX PubMed=12694290; DOI=10.1046/j.1365-294x.2003.01841.x;
RA Duvernell D.D., Schmidt P.S., Eanes W.F.;
RT "Clines and adaptive evolution in the methuselah gene region in Drosophila
RT melanogaster.";
RL Mol. Ecol. 12:1277-1285(2003).
RN [4]
RP REVIEW.
RX PubMed=10908591; DOI=10.1083/jcb.150.2.f83;
RA Brody T., Cravchik A.;
RT "Drosophila melanogaster G protein-coupled receptors.";
RL J. Cell Biol. 150:F83-F88(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B;
CC IsoId=Q9W0R5-1; Sequence=Displayed;
CC Name=A;
CC IsoId=Q9W0R5-2; Sequence=VSP_030270, VSP_030271;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000305}.
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DR EMBL; AE014296; AAF47378.2; -; Genomic_DNA.
DR EMBL; AE014296; AAO41210.2; -; Genomic_DNA.
DR EMBL; AF300364; AAK97869.1; -; Genomic_DNA.
DR EMBL; AF300363; AAK97869.1; JOINED; Genomic_DNA.
DR EMBL; AF300366; AAK97870.1; -; Genomic_DNA.
DR EMBL; AF300365; AAK97870.1; JOINED; Genomic_DNA.
DR EMBL; AF300368; AAK97871.1; -; Genomic_DNA.
DR EMBL; AF300367; AAK97871.1; JOINED; Genomic_DNA.
DR EMBL; AF300370; AAK97872.1; -; Genomic_DNA.
DR EMBL; AF300369; AAK97872.1; JOINED; Genomic_DNA.
DR EMBL; AF300372; AAK97873.1; -; Genomic_DNA.
DR EMBL; AF300371; AAK97873.1; JOINED; Genomic_DNA.
DR EMBL; AF300374; AAK97874.1; -; Genomic_DNA.
DR EMBL; AF300373; AAK97874.1; JOINED; Genomic_DNA.
DR EMBL; AF300376; AAK97875.1; -; Genomic_DNA.
DR EMBL; AF300375; AAK97875.1; JOINED; Genomic_DNA.
DR EMBL; AF300378; AAK97876.1; -; Genomic_DNA.
DR EMBL; AF300377; AAK97876.1; JOINED; Genomic_DNA.
DR EMBL; AF300380; AAK97877.1; -; Genomic_DNA.
DR EMBL; AF300379; AAK97877.1; JOINED; Genomic_DNA.
DR EMBL; AF300382; AAK97878.1; -; Genomic_DNA.
DR EMBL; AF300381; AAK97878.1; JOINED; Genomic_DNA.
DR EMBL; AF300384; AAK97879.1; -; Genomic_DNA.
DR EMBL; AF300383; AAK97879.1; JOINED; Genomic_DNA.
DR EMBL; AF300386; AAK97880.1; -; Genomic_DNA.
DR EMBL; AF300385; AAK97880.1; JOINED; Genomic_DNA.
DR EMBL; AF300388; AAK97881.1; -; Genomic_DNA.
DR EMBL; AF300387; AAK97881.1; JOINED; Genomic_DNA.
DR EMBL; AF300390; AAK97882.1; -; Genomic_DNA.
DR EMBL; AF300389; AAK97882.1; JOINED; Genomic_DNA.
DR EMBL; AF300392; AAK97883.1; -; Genomic_DNA.
DR EMBL; AF300391; AAK97883.1; JOINED; Genomic_DNA.
DR EMBL; AF300394; AAK97884.1; -; Genomic_DNA.
DR EMBL; AF300393; AAK97884.1; JOINED; Genomic_DNA.
DR EMBL; AF300396; AAK97885.1; -; Genomic_DNA.
DR EMBL; AF300395; AAK97885.1; JOINED; Genomic_DNA.
DR EMBL; AF300398; AAK97886.1; -; Genomic_DNA.
DR EMBL; AF300397; AAK97886.1; JOINED; Genomic_DNA.
DR EMBL; AF300400; AAK97887.1; -; Genomic_DNA.
DR EMBL; AF300399; AAK97887.1; JOINED; Genomic_DNA.
DR EMBL; AF300402; AAK97888.1; -; Genomic_DNA.
DR EMBL; AF300401; AAK97888.1; JOINED; Genomic_DNA.
DR EMBL; AF300404; AAK97889.1; -; Genomic_DNA.
DR EMBL; AF300403; AAK97889.1; JOINED; Genomic_DNA.
DR EMBL; AF300406; AAK97890.1; -; Genomic_DNA.
DR EMBL; AF300405; AAK97890.1; JOINED; Genomic_DNA.
DR EMBL; AF300408; AAK97891.1; -; Genomic_DNA.
DR EMBL; AF300407; AAK97891.1; JOINED; Genomic_DNA.
DR RefSeq; NP_612030.2; NM_138186.3. [Q9W0R5-2]
DR RefSeq; NP_788446.2; NM_176268.3. [Q9W0R5-1]
DR AlphaFoldDB; Q9W0R5; -.
DR BioGRID; 63613; 1.
DR STRING; 7227.FBpp0072472; -.
DR TCDB; 9.A.14.14.1; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q9W0R5; 7 sites.
DR PaxDb; Q9W0R5; -.
DR PRIDE; Q9W0R5; -.
DR EnsemblMetazoa; FBtr0072572; FBpp0072471; FBgn0035132. [Q9W0R5-2]
DR EnsemblMetazoa; FBtr0072573; FBpp0072472; FBgn0035132. [Q9W0R5-1]
DR GeneID; 38057; -.
DR KEGG; dme:Dmel_CG17061; -.
DR CTD; 38057; -.
DR FlyBase; FBgn0035132; mthl10.
DR VEuPathDB; VectorBase:FBgn0035132; -.
DR eggNOG; ENOG502R627; Eukaryota.
DR GeneTree; ENSGT00940000166745; -.
DR InParanoid; Q9W0R5; -.
DR PhylomeDB; Q9W0R5; -.
DR BioGRID-ORCS; 38057; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38057; -.
DR PRO; PR:Q9W0R5; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035132; Expressed in seminal fluid secreting gland and 34 other tissues.
DR ExpressionAtlas; Q9W0R5; baseline and differential.
DR Genevisible; Q9W0R5; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:FlyBase.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:FlyBase.
DR GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
DR CDD; cd00251; Mth_Ecto; 1.
DR Gene3D; 2.30.160.11; -; 1.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR044860; Methusela_ecto_dom_1.
DR InterPro; IPR010596; Methuselah_N_dom.
DR InterPro; IPR036272; Methuselah_N_sf.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF06652; Methuselah_N; 1.
DR SUPFAM; SSF63877; SSF63877; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..585
FT /note="Probable G-protein coupled receptor Mth-like 10"
FT /id="PRO_0000013031"
FT TOPO_DOM 33..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..312
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..404
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..466
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 488..498
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 520..585
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 142
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 56..110
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 112..117
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 121..216
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 122..135
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 177..236
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT VAR_SEQ 457..466
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000305"
FT /id="VSP_030270"
FT VAR_SEQ 532..585
FT /note="CSSVRDGSNQRQSQYSTKTTSSSVANLSLHEKPSVEKPLVISSSVDPQKTTI
FT FR -> TIRVRSLRQTESVTMGPTSFSMKQRFMDASNQIRKLVVIRNAFANGSTSGIHS
FT HEV (in isoform A)"
FT /evidence="ECO:0000305"
FT /id="VSP_030271"
FT VARIANT 150
FT /note="M -> V (in strain: ZIM(S)24)"
SQ SEQUENCE 585 AA; 67406 MW; F1DE309DA35F014C CRC64;
MPKKIHQPGG SLYCGVTLLG VLCLVVFRLI PGIPFGTYVM AERDHYHTID DPNVPCNFYD
TVNLTGHRLF PNGSYDYYGT IVPAELVGTY DYIHSSLTER IEVREHVRGC VCKFKSCLNI
CCPWRQVFNS EVDGCIIDHS DNRTWPDPPM LNITFRNEST ILVNMFTQFA IQSFRPCPKM
FSLQPETNNW DDYLLFENGS MLRVDDKLLI RKNEFCMVPT YVNESDMFYT IHPANCDMQD
DHSTVKIINS YAMMFSIPFM MLTIAVYLLI PELRNQHGKS LVCYLIGLSV GYSSLCYVQL
YQVDATGVTC KVFGYTAYFF FMGAYMWLSV ISFDLWHNFR GTRGINRFQE KKRFLFYSLY
SWGIALVFLA FTYCAQQLTN LPANLKPGIG DGVYCWLDMS NWAAMIYFYG PILAIVVANT
IMFIMTAIKI HGVQREMARI IASENSTKNL RTEKDKRFYR AWSNYRFGLF LRLFLIMGIT
WLTELISYFV GSDKGWSKLF YISDLANAMQ GFLIFMLFVM KKKVKHLITN RCSSVRDGSN
QRQSQYSTKT TSSSVANLSL HEKPSVEKPL VISSSVDPQK TTIFR
