MTH11_DROME
ID MTH11_DROME Reviewed; 532 AA.
AC P83118; A0A0B4KG61; Q8INM0;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Probable G-protein coupled receptor Mth-like 11;
DE AltName: Full=Protein methuselah-like 11;
DE Flags: Precursor;
GN Name=mthl11; Synonyms=Mth-like-11; ORFNames=CG31147;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=11274391; DOI=10.1073/pnas.051625298;
RA West A.P. Jr., Llamas L.L., Snow P.M., Benzer S., Bjorkman P.J.;
RT "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-
RT coupled receptor associated with extended lifespan.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3744-3749(2001).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=C {ECO:0000312|FlyBase:FBgn0045443};
CC IsoId=P83118-1; Sequence=Displayed;
CC Name=D {ECO:0000312|FlyBase:FBgn0045443};
CC IsoId=P83118-2; Sequence=VSP_059298;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000305}.
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DR EMBL; AE014297; AAN13470.3; -; Genomic_DNA.
DR EMBL; AE014297; AGB95847.1; -; Genomic_DNA.
DR RefSeq; NP_001262465.1; NM_001275536.1. [P83118-2]
DR RefSeq; NP_731479.3; NM_169343.4. [P83118-1]
DR AlphaFoldDB; P83118; -.
DR STRING; 7227.FBpp0304810; -.
DR GlyGen; P83118; 6 sites.
DR PaxDb; P83118; -.
DR PRIDE; P83118; -.
DR EnsemblMetazoa; FBtr0332552; FBpp0304810; FBgn0045443. [P83118-1]
DR EnsemblMetazoa; FBtr0332553; FBpp0304811; FBgn0045443. [P83118-2]
DR GeneID; 117467; -.
DR KEGG; dme:Dmel_CG31147; -.
DR CTD; 117467; -.
DR FlyBase; FBgn0045443; mthl11.
DR VEuPathDB; VectorBase:FBgn0045443; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000168274; -.
DR InParanoid; P83118; -.
DR OMA; WSAMYYF; -.
DR PhylomeDB; P83118; -.
DR BioGRID-ORCS; 117467; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 117467; -.
DR PRO; PR:P83118; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0045443; Expressed in gastrula and 3 other tissues.
DR ExpressionAtlas; P83118; differential.
DR Genevisible; P83118; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:FlyBase.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:FlyBase.
DR GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
DR CDD; cd00251; Mth_Ecto; 1.
DR Gene3D; 2.170.180.11; -; 1.
DR Gene3D; 2.30.160.11; -; 1.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR044860; Methusela_ecto_dom_1.
DR InterPro; IPR023311; Methusela_ecto_dom_2.
DR InterPro; IPR010596; Methuselah_N_dom.
DR InterPro; IPR036272; Methuselah_N_sf.
DR Pfam; PF06652; Methuselah_N; 1.
DR SUPFAM; SSF63877; SSF63877; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..532
FT /note="Probable G-protein coupled receptor Mth-like 11"
FT /id="PRO_0000013034"
FT TOPO_DOM 21..229
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..386
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..439
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 461..469
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..490
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 491..532
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 26..80
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 82..87
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 91..184
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 92..103
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 145..204
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT VAR_SEQ 215..231
FT /note="Missing (in isoform D)"
FT /id="VSP_059298"
SQ SEQUENCE 532 AA; 62092 MW; 164E30BE01FE1BAD CRC64;
MGMFRVEYLL LGILVIGVRS RDIPNCDFFD TVQLRESEKL CNGSYRYEDV VIPAKLTGKY
DYEIDYDGDR VSVPKHIRGC VCKLKTCIRF CCHHKKLMAG NLCSQDVYEN LTYEYTLDIT
QLNGSVIKKH VLNDMVVQQD LPLPCERHYS LDAETSTYDM WSLYENGSLF RHFDQRYLSK
QEFCLQPNPT STGKNYSLIV AFNCIQKPSM KMAYGRFECV RKSRLSNASI PVKFSSVFFM
VITIAAYLWL PKFRSLHGKC CNLYFICLAI TFLLNVISLF GIFELKTPIC YLTGYAGYFT
VMATFLWLSV ISFDVWRRFA MRKFQVFYKN KRSSFFNYNI IVWSSAGLLT CIIFLVDQFV
ETNLDNPYNP AVGVFSCWIF TNGWSATFYF YAPLAILIIL NCASFFLTTR YIYVENKQNQ
KVLNNSEPQK LSRNHANYRI YFRLFIIMGG SWFLEIIAFI CEMENMWKPL IILNDYINCS
QGIIIFVATF CNHEMFRLIR KRIQNRNITS LELTNTSRPV ESEKMADVEL GK
