MTH1_DROME
ID MTH1_DROME Reviewed; 676 AA.
AC Q9VXD9;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Probable G-protein coupled receptor Mth-like 1;
DE AltName: Full=Protein methuselah-like 1;
DE Flags: Precursor;
GN Name=mthl1; ORFNames=CG4521;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP REVIEW.
RX PubMed=10908591; DOI=10.1083/jcb.150.2.f83;
RA Brody T., Cravchik A.;
RT "Drosophila melanogaster G protein-coupled receptors.";
RL J. Cell Biol. 150:F83-F88(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000305}.
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DR EMBL; AE014298; AAF48635.1; -; Genomic_DNA.
DR EMBL; AY118371; AAM48400.1; -; mRNA.
DR RefSeq; NP_001285340.1; NM_001298411.1.
DR RefSeq; NP_573140.1; NM_132912.2.
DR AlphaFoldDB; Q9VXD9; -.
DR SMR; Q9VXD9; -.
DR BioGRID; 58973; 2.
DR STRING; 7227.FBpp0074089; -.
DR GlyGen; Q9VXD9; 4 sites.
DR PaxDb; Q9VXD9; -.
DR PRIDE; Q9VXD9; -.
DR DNASU; 32637; -.
DR EnsemblMetazoa; FBtr0074314; FBpp0074089; FBgn0030766.
DR EnsemblMetazoa; FBtr0340150; FBpp0309136; FBgn0030766.
DR GeneID; 32637; -.
DR KEGG; dme:Dmel_CG4521; -.
DR CTD; 32637; -.
DR FlyBase; FBgn0030766; mthl1.
DR VEuPathDB; VectorBase:FBgn0030766; -.
DR eggNOG; KOG4193; Eukaryota.
DR HOGENOM; CLU_002753_3_0_1; -.
DR InParanoid; Q9VXD9; -.
DR OMA; HALHWRC; -.
DR OrthoDB; 1153592at2759; -.
DR PhylomeDB; Q9VXD9; -.
DR BioGRID-ORCS; 32637; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 32637; -.
DR PRO; PR:Q9VXD9; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030766; Expressed in cleaving embryo and 35 other tissues.
DR ExpressionAtlas; Q9VXD9; baseline and differential.
DR Genevisible; Q9VXD9; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IPI:FlyBase.
DR GO; GO:0070252; P:actin-mediated cell contraction; IGI:FlyBase.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:FlyBase.
DR GO; GO:0007369; P:gastrulation; IMP:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IGI:FlyBase.
DR GO; GO:0048383; P:mesectoderm development; IMP:FlyBase.
DR GO; GO:0007509; P:mesoderm migration involved in gastrulation; IMP:FlyBase.
DR GO; GO:0043519; P:regulation of myosin II filament organization; IMP:FlyBase.
DR GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
DR GO; GO:0007472; P:wing disc morphogenesis; IMP:FlyBase.
DR Gene3D; 2.170.180.11; -; 1.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR023311; Methusela_ecto_dom_2.
DR Pfam; PF00002; 7tm_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..37
FT /evidence="ECO:0000255"
FT CHAIN 38..676
FT /note="Probable G-protein coupled receptor Mth-like 1"
FT /id="PRO_0000013023"
FT TOPO_DOM 38..335
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..365
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 387..403
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 425..441
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 463..488
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..509
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 510..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 541..561
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 562
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 563..583
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 584..676
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 609..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 486
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 198..283
FT /evidence="ECO:0000250"
FT DISULFID 199..212
FT /evidence="ECO:0000250"
FT DISULFID 246..298
FT /evidence="ECO:0000250"
SQ SEQUENCE 676 AA; 74466 MW; 99814D3D1300ACFD CRC64;
MDRSRSSRAA SSNQFIRPCG LLTTVILLQT LVSMSLAIEE MSPPPAAPPR PSPPPTVKLN
KCCHSGEYLN DGTCIAGSEA LWLPMVYLVQ QQRFFEPHGA SPRFLKFLPN TRPTCRKDQT
TEIFRSRGAN VMLFPNGTLY VRERALMVQP SDYCVDWEVA VVCLNDSQPI NALEDPDYAA
NPLVQQEPPK ASLRLSKCCG KWGSYNTQLQ NCDLQPNHQA AVDGLLRLSP QLPEGSYQTS
YGLPDCGQPG GYSIAGDWQD AKLDRNTAML QLPHKNLSAG QYCLEHTQRE GEVKIIACQH
LFSSAAGAGI HDGSIGGTIE QANGQNLQKA VLTGGILVSI VFLSATLVAG FLLPAVHHAL
HWRCQICYVT CLLFGKILLA IEELSSSLQP GSAACHTLAI TMQFFFLAAF FWLNTMCFNI
WWTFRDFRPS SLERNQEALR RYLYSLYAWG GPLLITFVAA CVDQLPETTL LRPGFGQLYC
WFDNRNLSIF AYFYGPIGLL LCANIALFVS TTHQLTCGLW KRDDVKSSSE KSALGRVCLK
LVVVMGVTWI ADILSWLVGG PHGVWFFTDL INALQGVFIF IVVGCQPQVW TACRRIFCPR
LRHDITNTTN GVQHSSSSQG LPSMAGGTEI TQNTTTTTTT TNTTATHMPS NPAEDEVPEK
APIAPVAPIV KMETIC
