MTH1_YEAST
ID MTH1_YEAST Reviewed; 433 AA.
AC P35198; D6VSQ8;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein MTH1;
GN Name=MTH1; OrderedLocusNames=YDR277C; ORFNames=D9954.12;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8114728; DOI=10.1128/mcb.14.3.1972-1978.1994;
RA Hubbard E.J.A., Jiang R., Carlson M.;
RT "Dosage-dependent modulation of glucose repression by MSN3 (STD1) in
RT Saccharomyces cerevisiae.";
RL Mol. Cell. Biol. 14:1972-1978(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- INTERACTION:
CC P35198; P02829: HSP82; NbExp=3; IntAct=EBI-11561, EBI-8659;
CC -!- SIMILARITY: To yeast STD1/MSN3. {ECO:0000305}.
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DR EMBL; L21933; AAA18536.1; -; Unassigned_DNA.
DR EMBL; U51030; AAB64457.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12118.1; -; Genomic_DNA.
DR PIR; S46668; S46668.
DR RefSeq; NP_010563.3; NM_001180585.3.
DR AlphaFoldDB; P35198; -.
DR SMR; P35198; -.
DR BioGRID; 32330; 113.
DR DIP; DIP-803N; -.
DR IntAct; P35198; 14.
DR MINT; P35198; -.
DR STRING; 4932.YDR277C; -.
DR iPTMnet; P35198; -.
DR PaxDb; P35198; -.
DR PRIDE; P35198; -.
DR EnsemblFungi; YDR277C_mRNA; YDR277C; YDR277C.
DR GeneID; 851870; -.
DR KEGG; sce:YDR277C; -.
DR SGD; S000002685; MTH1.
DR VEuPathDB; FungiDB:YDR277C; -.
DR eggNOG; ENOG502QPKX; Eukaryota.
DR GeneTree; ENSGT00940000176732; -.
DR HOGENOM; CLU_049491_0_0_1; -.
DR InParanoid; P35198; -.
DR OMA; ANLDYEF; -.
DR BioCyc; YEAST:G3O-29843-MON; -.
DR PRO; PR:P35198; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P35198; protein.
DR GO; GO:1904659; P:glucose transmembrane transport; IMP:SGD.
DR GO; GO:0007165; P:signal transduction; IMP:SGD.
DR InterPro; IPR035189; Std1/Mth1.
DR Pfam; PF17235; STD1; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..433
FT /note="Protein MTH1"
FT /id="PRO_0000096625"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 433 AA; 49060 MW; 3A23EF4742632761 CRC64;
MFVSPPPATS KNQVLQRRPL ESTNSNHGFA SSLQAIPENT MSGSDNASFQ SLPLSMSSSQ
STTSSRRENF VNAPPEYTDR ARDEIKKRLL ASSPSRRSHH SSSMHSASRR SSVAESGSLL
SDNASSYQSS IFSAPSTVHT QLTNDSSFSE FPNHKLITRV SLDEALPKTF YDMYSPDILL
ADPSNILCNG RPKFTKRELL DWDLNDIRSL LIVEKLRPEW GNQLPEVITV GDNMPQFRLQ
LLPLYSSDET IIATLVHSDL YMEANLDYEF KLTSAKYTVA TARKRHEHIT GRNEAVMNLS
KPEWRNIIEN YLLNIAVEAQ CRFDFKQRCS EYKKWKLQQS NLKRPDMPPP SIIPRKNSTE
TKSLLKKALL KNIQLKNPNN NLDELMMRSS AATNQQGKNK VSLSKEEKAT IWSQCQAQVY
QRLGLDWQPD SVS
