MTH5_DROME
ID MTH5_DROME Reviewed; 496 AA.
AC Q9VGG8; Q8MRB8;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2003, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Probable G-protein coupled receptor Mth-like 5;
DE AltName: Full=Protein methuselah-like 5;
GN Name=mthl5; ORFNames=CG6965;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP REVIEW.
RX PubMed=10908591; DOI=10.1083/jcb.150.2.f83;
RA Brody T., Cravchik A.;
RT "Drosophila melanogaster G protein-coupled receptors.";
RL J. Cell Biol. 150:F83-F88(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000305}.
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DR EMBL; AE014297; AAF54714.3; -; Genomic_DNA.
DR EMBL; AY121676; AAM52003.1; -; mRNA.
DR RefSeq; NP_650126.2; NM_141869.3.
DR AlphaFoldDB; Q9VGG8; -.
DR SMR; Q9VGG8; -.
DR BioGRID; 66557; 1.
DR STRING; 7227.FBpp0081989; -.
DR GlyGen; Q9VGG8; 1 site.
DR PaxDb; Q9VGG8; -.
DR PRIDE; Q9VGG8; -.
DR DNASU; 41438; -.
DR EnsemblMetazoa; FBtr0082515; FBpp0081989; FBgn0037960.
DR GeneID; 41438; -.
DR KEGG; dme:Dmel_CG6965; -.
DR CTD; 41438; -.
DR FlyBase; FBgn0037960; mthl5.
DR VEuPathDB; VectorBase:FBgn0037960; -.
DR eggNOG; KOG4193; Eukaryota.
DR InParanoid; Q9VGG8; -.
DR OMA; NTYGRIH; -.
DR PhylomeDB; Q9VGG8; -.
DR BioGRID-ORCS; 41438; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41438; -.
DR PRO; PR:Q9VGG8; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037960; Expressed in wing disc and 45 other tissues.
DR ExpressionAtlas; Q9VGG8; baseline and differential.
DR Genevisible; Q9VGG8; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:FlyBase.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:FlyBase.
DR GO; GO:0003007; P:heart morphogenesis; IMP:FlyBase.
DR GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..496
FT /note="Probable G-protein coupled receptor Mth-like 5"
FT /id="PRO_0000195160"
FT TOPO_DOM 1..219
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 349..366
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 388..411
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..438
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 460..496
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 63
FT /note="V -> F (in Ref. 3; AAM52003)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 496 AA; 56351 MW; 2D6EDF1A9F864E33 CRC64;
MLVKTLGAHF AAGQNAKKCS CCALLISLLC VLLLSLNPLP VTSHVTSAGS STALSSDPNL
VLVNKCCEKF EIHVDHECQQ VNETDYFQPM FTSYGGEQNR PVKFKFVIGI PNCGSMQMWP
IYHYAGSSDK LVLLDDGRLR HYTNAENEAE ERHGIQSDYE EDIAGSLEPL YHDYDKGLYC
IDKATSSTGE ENVLFANICL ARKEIKWSDS NFLLRKILNP IFHGISLVIL LVIAIIYFIL
PTLRDLVGNI VTTIAMCLMV SQAADLVRIF TELTSHVSFI VADIILCFSL LAAFFWLNSF
GFYIWKTFRS RNVFLRVTDG RKYCYYSAYA WGCTATMAAL AVFAHFFLDA ESYKQEHMVG
EQETIGWLGI CIFFAPIACT ILVNIFFYVT TRKLINRRTV YGRIAHKLKA NFIMFSLMLL
VMSIAWLFLI MSWLQMEGLL YAHIVVNALQ TPLLLYICVL RQRHVTFLLK KTCCYNEPPS
ANDWGDELHY MNGNDY
