MTH6_DROME
ID MTH6_DROME Reviewed; 480 AA.
AC Q9VS77;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2003, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Probable G-protein coupled receptor Mth-like 6;
DE AltName: Full=Protein methuselah-like 6;
DE Flags: Precursor;
GN Name=mthl6; ORFNames=CG16992;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP REVIEW.
RX PubMed=10908591; DOI=10.1083/jcb.150.2.f83;
RA Brody T., Cravchik A.;
RT "Drosophila melanogaster G protein-coupled receptors.";
RL J. Cell Biol. 150:F83-F88(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000305}.
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DR EMBL; AE014296; AAO41272.1; -; Genomic_DNA.
DR RefSeq; NP_788473.1; NM_176295.2.
DR AlphaFoldDB; Q9VS77; -.
DR SMR; Q9VS77; -.
DR STRING; 7227.FBpp0076503; -.
DR GlyGen; Q9VS77; 3 sites.
DR PaxDb; Q9VS77; -.
DR EnsemblMetazoa; FBtr0076789; FBpp0076503; FBgn0035789.
DR GeneID; 38839; -.
DR KEGG; dme:Dmel_CG16992; -.
DR CTD; 38839; -.
DR FlyBase; FBgn0035789; mthl6.
DR VEuPathDB; VectorBase:FBgn0035789; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000166745; -.
DR HOGENOM; CLU_002753_3_0_1; -.
DR InParanoid; Q9VS77; -.
DR OMA; RCWINTY; -.
DR OrthoDB; 1153592at2759; -.
DR PhylomeDB; Q9VS77; -.
DR BioGRID-ORCS; 38839; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38839; -.
DR PRO; PR:Q9VS77; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035789; Expressed in embryonic/larval hemocyte (Drosophila) and 6 other tissues.
DR Genevisible; Q9VS77; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:FlyBase.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:FlyBase.
DR GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
DR CDD; cd00251; Mth_Ecto; 1.
DR Gene3D; 2.170.180.11; -; 1.
DR Gene3D; 2.30.160.11; -; 1.
DR InterPro; IPR022343; GCR1-cAMP_receptor.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR044860; Methusela_ecto_dom_1.
DR InterPro; IPR023311; Methusela_ecto_dom_2.
DR InterPro; IPR010596; Methuselah_N_dom.
DR InterPro; IPR036272; Methuselah_N_sf.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF06652; Methuselah_N; 1.
DR PRINTS; PR02001; GCR1CAMPR.
DR SUPFAM; SSF63877; SSF63877; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..480
FT /note="Probable G-protein coupled receptor Mth-like 6"
FT /id="PRO_0000013027"
FT TOPO_DOM 21..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..225
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..254
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..263
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..283
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..326
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..356
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..379
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 380..405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..428
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 429..437
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..457
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 458..480
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 25..78
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 80..85
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 89..179
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 90..101
FT /evidence="ECO:0000250|UniProtKB:O97148"
SQ SEQUENCE 480 AA; 56079 MW; 6553CF7AC9F57A63 CRC64;
MLLNILAIIL VFVISSQSEA VIPGCDYFDT VDISHIPKLN DSYAYEELII PAHLTGLYTF
RQLADGSQEP VKSHLRACIC KLKPCIRFCC PRNKMMPNSR CSDGLTENLK RINPYLKITL
EDGTIGKYYL LTDMIVLRYE FRYCEKVVSV QEDQYKLYEN GSFMIKPDVN WTLSKQWYCL
HPRLEDPNSI WILEHVYIPK SMPAVPQVGT ISMVGCILTI AVYLYIKKLR NLLGKCFICY
VFCKFVQYLI WAGGDLNLWN NICSLAGYTN YFFALASHFW LSVMSHQIWK NLRLINRDER
SYHFLIYNIY GWGTPAIMTA ITYLVDWAWE DRPDKLNWIP GVGLYRCWIN TYDWSAMIYL
YGPMLILSLF NVVTFILTVN HIMKIKSSVK SSTQQQRKCI QNNDFLLYLR LSVMMGVTGI
SEVITYFVKR HKFWRQVLRV PNFFHLGSGI VVFVLFILKR STFQMIMERI SGPRRQQPAS
