MTH7_DROME
ID MTH7_DROME Reviewed; 491 AA.
AC Q9VSE7;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 25-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Probable G-protein coupled receptor Mth-like 7;
DE AltName: Full=Protein methuselah-like 7;
DE Flags: Precursor;
GN Name=mthl7; ORFNames=CG7476;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP REVIEW.
RX PubMed=10908591; DOI=10.1083/jcb.150.2.f83;
RA Brody T., Cravchik A.;
RT "Drosophila melanogaster G protein-coupled receptors.";
RL J. Cell Biol. 150:F83-F88(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q9VSE7-2; Sequence=Displayed;
CC Name=B;
CC IsoId=Q9VSE7-1; Sequence=VSP_010782;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000305}.
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DR EMBL; AE014296; AAF50475.2; -; Genomic_DNA.
DR EMBL; AE014296; AAO41271.1; -; Genomic_DNA.
DR RefSeq; NP_648181.2; NM_139924.3. [Q9VSE7-2]
DR RefSeq; NP_788475.1; NM_176297.1. [Q9VSE7-1]
DR AlphaFoldDB; Q9VSE7; -.
DR SMR; Q9VSE7; -.
DR STRING; 7227.FBpp0076449; -.
DR GlyGen; Q9VSE7; 3 sites.
DR PaxDb; Q9VSE7; -.
DR EnsemblMetazoa; FBtr0076726; FBpp0076449; FBgn0035847. [Q9VSE7-2]
DR EnsemblMetazoa; FBtr0076727; FBpp0076450; FBgn0035847. [Q9VSE7-1]
DR GeneID; 38910; -.
DR KEGG; dme:Dmel_CG7476; -.
DR CTD; 38910; -.
DR FlyBase; FBgn0035847; mthl7.
DR VEuPathDB; VectorBase:FBgn0035847; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000166745; -.
DR InParanoid; Q9VSE7; -.
DR OMA; GRIGCIN; -.
DR PhylomeDB; Q9VSE7; -.
DR BioGRID-ORCS; 38910; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38910; -.
DR PRO; PR:Q9VSE7; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Genevisible; Q9VSE7; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:FlyBase.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:FlyBase.
DR GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
DR Gene3D; 2.170.180.11; -; 1.
DR Gene3D; 2.30.160.11; -; 1.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR044860; Methusela_ecto_dom_1.
DR InterPro; IPR023311; Methusela_ecto_dom_2.
DR InterPro; IPR010596; Methuselah_N_dom.
DR InterPro; IPR036272; Methuselah_N_sf.
DR Pfam; PF06652; Methuselah_N; 1.
DR SUPFAM; SSF63877; SSF63877; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..491
FT /note="Probable G-protein coupled receptor Mth-like 7"
FT /id="PRO_0000013028"
FT TOPO_DOM 23..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..252
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..372
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..434
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 456..458
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 480..491
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..80
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 82..87
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 92..103
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT VAR_SEQ 160..175
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_010782"
SQ SEQUENCE 491 AA; 57383 MW; 4FBBC9FDC80F0F14 CRC64;
MRLPWVIFCT VLLLIFTNNS NADIPGCNYY DTVDISYIER QNDSYLYDDI EIPASLTGYY
EFRQFGDGSI TPIEKHLRAC VCSVRPCIRI CCPAKNFLAN GKCDDGLKEE LARFKPYIYF
TYMDLQARVP LTDMAIIRDE FFDCDEMIYI SDFNYFLEEV SIQIFNKCGL IVWFQDGKFW
VTVDLFMEKQ DYCLYRHNFD SDFPKSMWII RHRCTSHISP GSLEILIITM ICFVLTIAVY
LYIKKLRNVT GKCIVCCIVS RFIQCLIMIL DHLNLLNGIC SPAGYSSHFF RMASNLWLSV
ISYHTWKVLT SLNRVDPNYR FLRYNAFVWS TAAIMTGSIY IVNQIWENDP SKWNWLPLVG
FIRCSVKDWH PSVWIYISGP SLALSTFNVA MFALTAIYIR KVKGGINKFT NEEEGRINCI
NFDSQTYLQF LRLSIVMGLT WIFNVIPYSA RLHIFWEWVG IISEYFHSAF GIVLFVLLVL
KRSTWTLMMD S
