MTH9_DROME
ID MTH9_DROME Reviewed; 513 AA.
AC Q9W0R6;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Probable G-protein coupled receptor Mth-like 9;
DE AltName: Full=Protein methuselah-like 9;
DE Flags: Precursor;
GN Name=mthl9; ORFNames=CG17084;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP REVIEW.
RX PubMed=10908591; DOI=10.1083/jcb.150.2.f83;
RA Brody T., Cravchik A.;
RT "Drosophila melanogaster G protein-coupled receptors.";
RL J. Cell Biol. 150:F83-F88(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000305}.
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DR EMBL; AE014296; AAF47377.1; -; Genomic_DNA.
DR EMBL; AY070598; AAL48069.1; -; mRNA.
DR EMBL; AY113401; AAM29406.1; -; mRNA.
DR RefSeq; NP_612029.1; NM_138185.4.
DR AlphaFoldDB; Q9W0R6; -.
DR SMR; Q9W0R6; -.
DR BioGRID; 63612; 1.
DR DIP; DIP-22552N; -.
DR IntAct; Q9W0R6; 1.
DR STRING; 7227.FBpp0072473; -.
DR GlyGen; Q9W0R6; 4 sites.
DR PaxDb; Q9W0R6; -.
DR DNASU; 38056; -.
DR EnsemblMetazoa; FBtr0072574; FBpp0072473; FBgn0035131.
DR GeneID; 38056; -.
DR KEGG; dme:Dmel_CG17084; -.
DR CTD; 38056; -.
DR FlyBase; FBgn0035131; mthl9.
DR VEuPathDB; VectorBase:FBgn0035131; -.
DR eggNOG; ENOG502TGKW; Eukaryota.
DR GeneTree; ENSGT00940000170903; -.
DR HOGENOM; CLU_002753_3_0_1; -.
DR InParanoid; Q9W0R6; -.
DR OMA; LNCERFQ; -.
DR OrthoDB; 1153592at2759; -.
DR PhylomeDB; Q9W0R6; -.
DR BioGRID-ORCS; 38056; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38056; -.
DR PRO; PR:Q9W0R6; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035131; Expressed in embryonic/larval gut (Drosophila) and 28 other tissues.
DR Genevisible; Q9W0R6; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:FlyBase.
DR GO; GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:FlyBase.
DR GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
DR CDD; cd00251; Mth_Ecto; 1.
DR Gene3D; 2.170.180.11; -; 1.
DR Gene3D; 2.30.160.11; -; 1.
DR InterPro; IPR044860; Methusela_ecto_dom_1.
DR InterPro; IPR023311; Methusela_ecto_dom_2.
DR InterPro; IPR010596; Methuselah_N_dom.
DR InterPro; IPR036272; Methuselah_N_sf.
DR Pfam; PF06652; Methuselah_N; 1.
DR SUPFAM; SSF63877; SSF63877; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..513
FT /note="Probable G-protein coupled receptor Mth-like 9"
FT /id="PRO_0000013030"
FT TOPO_DOM 20..207
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..360
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..403
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 425..438
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 460..513
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 29..82
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 84..89
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 93..181
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 94..107
FT /evidence="ECO:0000250|UniProtKB:O97148"
SQ SEQUENCE 513 AA; 59039 MW; 9F0B25A5098A314C CRC64;
MVSPLIILLI IWLSVGAKSV EIASINHPCA YAHTVNITDG LRMKDGSYSY AGVVVPPHLM
AEYSFKVIDG VEYRAKKHLR GCVCLLKPCI SFCCPENLVF DAKHWNCTMP HQVRESTHVE
LTYANRTVDQ VRIRDRFVVR TELGCRNKFV DKKHDNFWQW DLFENGTLRR DNRLWSTDEY
CFSPLEHNPE QWELTPLNCE RFQTGYRVWI YAICSIIAII INIFILSLLG SVRDARKSHY
GQLIIYYLLS MIVGYSLLVY LALKNPMKLS HVACRNIGFL AYFCIMLSFV FLAICSLDFL
LKFKQKAVRS SVRRLSLALA VLAVIGLRFL VSLAQDSKLP KHFKPGMGED YCWFDVRTWG
ILIYYYGPIA LLLIFSIVCC LKAYFSIYEL PPDTQYILGT QLKIVKTHFY AFSAYIVGVF
AVWIREIVVY IMARVREHFF IIDFWSGICI LGLAIAGFIL LLGKNLHVKS WWAINVESSQ
TDLSIINARV YKFDEKGDLK SSDSPYKPTV TSL
