ID   MTHSD_BOVIN             Reviewed;         380 AA.
AC   Q2KI24;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Methenyltetrahydrofolate synthase domain-containing protein;
GN   Name=MTHFSD;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC112796; AAI12797.1; -; mRNA.
DR   RefSeq; NP_001039507.1; NM_001046042.1.
DR   AlphaFoldDB; Q2KI24; -.
DR   SMR; Q2KI24; -.
DR   STRING; 9913.ENSBTAP00000032495; -.
DR   PaxDb; Q2KI24; -.
DR   PRIDE; Q2KI24; -.
DR   Ensembl; ENSBTAT00000032564; ENSBTAP00000032495; ENSBTAG00000012446.
DR   GeneID; 509897; -.
DR   KEGG; bta:509897; -.
DR   CTD; 64779; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012446; -.
DR   VGNC; VGNC:31732; MTHFSD.
DR   eggNOG; KOG4410; Eukaryota.
DR   GeneTree; ENSGT00390000011730; -.
DR   HOGENOM; CLU_031500_3_0_1; -.
DR   InParanoid; Q2KI24; -.
DR   OMA; KTVYMAV; -.
DR   OrthoDB; 1137978at2759; -.
DR   TreeFam; TF324742; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000012446; Expressed in laryngeal cartilage and 104 other tissues.
DR   ExpressionAtlas; Q2KI24; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.40.50.10420; -; 1.
DR   InterPro; IPR002698; FTHF_cligase.
DR   InterPro; IPR024185; FTHF_cligase-like_sf.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR13017; PTHR13017; 1.
DR   Pfam; PF01812; 5-FTHF_cyc-lig; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..380
FT                   /note="Methenyltetrahydrofolate synthase domain-containing
FT                   protein"
FT                   /id="PRO_0000295870"
FT   DOMAIN          282..355
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          245..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   380 AA;  41483 MW;  323FBF80925983AF CRC64;
     MEPRAGVSKQ DIREQIWDYM ESQNLADFPR PVHHRIPNFK GASRAAEHFP RLQAFKMART
     IKVNPDAPQK NARFFVLESK KTLLVPTPRL RTGLFNKITP PPGATKDILR KCATSQGVRN
     YSTPVGLDSK VLVDLVVVGS VAVSEKGWRI GKGEGYADLE YAMMVSMGAV SQGTPVVTIV
     HDCQVVDIPE ALLEDHDLTV DYILTPTRVI TTGCERPKPA GIAWSKISCE MLGKMPILRS
     LRHQEEQAGK DVTLRDGPRS PPGATRSPRD LAPPELGSVP LSSVQIGNLP RDARVSELKR
     ALSALGVAPS RLTWQGPQHG AFLHYRDPAE AQQAIACLQG FRLGANTVRV VLARQQRASD
     LVGSHTAEPL PDHQPAIAGP