ID   MTHSD_DANRE             Reviewed;         382 AA.
AC   Q0P464;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Methenyltetrahydrofolate synthase domain-containing protein;
GN   Name=mthfsd; ORFNames=zgc:153374;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC122258; AAI22259.1; -; mRNA.
DR   RefSeq; NP_001038564.1; NM_001045099.1.
DR   AlphaFoldDB; Q0P464; -.
DR   SMR; Q0P464; -.
DR   STRING; 7955.ENSDARP00000090099; -.
DR   PaxDb; Q0P464; -.
DR   PRIDE; Q0P464; -.
DR   Ensembl; ENSDART00000099326; ENSDARP00000090099; ENSDARG00000062042.
DR   GeneID; 566203; -.
DR   KEGG; dre:566203; -.
DR   CTD; 64779; -.
DR   ZFIN; ZDB-GENE-030131-3513; mthfsd.
DR   eggNOG; KOG4410; Eukaryota.
DR   GeneTree; ENSGT00390000011730; -.
DR   HOGENOM; CLU_031500_3_0_1; -.
DR   InParanoid; Q0P464; -.
DR   OMA; KTVYMAV; -.
DR   OrthoDB; 1137978at2759; -.
DR   PhylomeDB; Q0P464; -.
DR   TreeFam; TF324742; -.
DR   PRO; PR:Q0P464; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 18.
DR   Bgee; ENSDARG00000062042; Expressed in liver and 15 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd12270; RRM_MTHFSD; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.40.50.10420; -; 1.
DR   InterPro; IPR002698; FTHF_cligase.
DR   InterPro; IPR024185; FTHF_cligase-like_sf.
DR   InterPro; IPR034359; MTHFSD_RRM.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   PANTHER; PTHR13017; PTHR13017; 1.
DR   Pfam; PF01812; 5-FTHF_cyc-lig; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..382
FT                   /note="Methenyltetrahydrofolate synthase domain-containing
FT                   protein"
FT                   /id="PRO_0000295874"
FT   DOMAIN          306..382
FT                   /note="RRM"
SQ   SEQUENCE   382 AA;  43084 MW;  315A5B1E5276FBD9 CRC64;
     MEPVIKINQG ETKWDVRHKV WNYIEVKNLA NFPRPVHNRI PNFKGALEAC NKVAQLEIFI
     ESAVVKVDPD KPMEGVRLAA LKARKSLLVP TPRLRFGLFN RITPPKGATK ETLRVCSTSQ
     GIKEFSVPVG LDDKVQVDLV VVGSVAVSEK GYRIGKGEGF ADMEYAMMAC MGSVTESTWV
     ITVVHDCQVM DIPEELIERH DLMVDFIITA TRVIKTECKH PKPQGIIWSM LHKEELKKIP
     ILKKLRTLEQ EAGKDVALKL IHAGEDEYRK SKELQWQSHP KADLEFKCLA SNSDRCSGFE
     PKFPTTTVYL SDIPPALRVS ELKGLLREQE VVPLQIRWQG AKRKAFLLYA DFTGAERATA
     ILQKLFINGH TIQAKCVSSQ KM