MTHSD_MOUSE
ID MTHSD_MOUSE Reviewed; 372 AA.
AC Q3URQ7; Q80WS4; Q8BUM0;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Methenyltetrahydrofolate synthase domain-containing protein;
GN Name=Mthfsd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3URQ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3URQ7-2; Sequence=VSP_027116;
CC Name=3;
CC IsoId=Q3URQ7-3; Sequence=VSP_027117, VSP_027118;
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DR EMBL; AK083317; BAC38863.1; -; mRNA.
DR EMBL; AK141278; BAE24631.1; -; mRNA.
DR EMBL; BC052066; AAH52066.1; -; mRNA.
DR CCDS; CCDS22723.1; -. [Q3URQ7-2]
DR CCDS; CCDS52691.1; -. [Q3URQ7-1]
DR RefSeq; NP_001159954.1; NM_001166482.1. [Q3URQ7-1]
DR RefSeq; NP_766349.1; NM_172761.3. [Q3URQ7-2]
DR RefSeq; XP_006531004.1; XM_006530941.2.
DR AlphaFoldDB; Q3URQ7; -.
DR SMR; Q3URQ7; -.
DR BioGRID; 231582; 1.
DR STRING; 10090.ENSMUSP00000112116; -.
DR iPTMnet; Q3URQ7; -.
DR PhosphoSitePlus; Q3URQ7; -.
DR EPD; Q3URQ7; -.
DR MaxQB; Q3URQ7; -.
DR PaxDb; Q3URQ7; -.
DR PRIDE; Q3URQ7; -.
DR ProteomicsDB; 291364; -. [Q3URQ7-1]
DR ProteomicsDB; 291365; -. [Q3URQ7-2]
DR ProteomicsDB; 291366; -. [Q3URQ7-3]
DR Antibodypedia; 30664; 121 antibodies from 20 providers.
DR DNASU; 234814; -.
DR Ensembl; ENSMUST00000047282; ENSMUSP00000044172; ENSMUSG00000031816. [Q3URQ7-2]
DR Ensembl; ENSMUST00000116415; ENSMUSP00000112116; ENSMUSG00000031816. [Q3URQ7-1]
DR GeneID; 234814; -.
DR KEGG; mmu:234814; -.
DR UCSC; uc009nro.1; mouse. [Q3URQ7-1]
DR CTD; 64779; -.
DR MGI; MGI:2679252; Mthfsd.
DR VEuPathDB; HostDB:ENSMUSG00000031816; -.
DR eggNOG; KOG4410; Eukaryota.
DR GeneTree; ENSGT00390000011730; -.
DR HOGENOM; CLU_031500_3_0_1; -.
DR InParanoid; Q3URQ7; -.
DR OMA; KTVYMAV; -.
DR OrthoDB; 1137978at2759; -.
DR PhylomeDB; Q3URQ7; -.
DR TreeFam; TF324742; -.
DR BioGRID-ORCS; 234814; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Mthfsd; mouse.
DR PRO; PR:Q3URQ7; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3URQ7; protein.
DR Bgee; ENSMUSG00000031816; Expressed in ear vesicle and 168 other tissues.
DR ExpressionAtlas; Q3URQ7; baseline and differential.
DR Genevisible; Q3URQ7; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.40.50.10420; -; 1.
DR InterPro; IPR002698; FTHF_cligase.
DR InterPro; IPR024185; FTHF_cligase-like_sf.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR13017; PTHR13017; 1.
DR Pfam; PF01812; 5-FTHF_cyc-lig; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; RNA-binding.
FT CHAIN 1..372
FT /note="Methenyltetrahydrofolate synthase domain-containing
FT protein"
FT /id="PRO_0000295872"
FT DOMAIN 296..369
FT /note="RRM"
FT REGION 246..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..19
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027116"
FT VAR_SEQ 148..234
FT /note="WRIGKGEGYADLEYAMMVSMGAVHKGTPVVTIVHDCQVVDIPEALVEDHDLT
FT VDYILTPTRVITTGCARPKPTGIMWSKVSCEMLTK -> KLETGCLDVPEGYPGHSPLA
FT CVHAESLTSAPVPLTLQAFCCSVSPHGRLSVIGMGGIESLSHLNQHSVERPLPGLCGGP
FT LMVVVIPH (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027117"
FT VAR_SEQ 235..372
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027118"
SQ SEQUENCE 372 AA; 40789 MW; CB548769D9AC7496 CRC64;
METQEGVSKQ SIRERIWDYM ESHDIADFPR PVHHRIPNFK GAAQAAGHLP HLQAFHVART
IKVNPDAPQR NARFLVLESK KTLLVPTPRL RTGLFNKITP PPGATKDILR KCATSQGVRN
FSVPVGLDSS VLVDLVVVGS VAVSEKGWRI GKGEGYADLE YAMMVSMGAV HKGTPVVTIV
HDCQVVDIPE ALVEDHDLTV DYILTPTRVI TTGCARPKPT GIMWSKVSCE MLTKIPVLRN
LREREKQAGK DVTLRDEPGS QQPAPGPIRR PQDRPQTGSR GGSRSPLQGA DTQLAATVCV
GNLPFTTRVR ELKRVLQELG VVPLRLTWQG PQHRAVLHYT DSAAAQQAAS LLQGLRLGAN
ALRVSLGQQR DM
