ID   MTHSD_XENLA             Reviewed;         415 AA.
AC   Q52L34; Q6AXA2;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Methenyltetrahydrofolate synthase domain-containing protein;
GN   Name=mthfsd;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 2-415 (ISOFORM 2).
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q52L34-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q52L34-2; Sequence=VSP_027119;
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DR   EMBL; BC079691; AAH79691.1; -; mRNA.
DR   EMBL; BC094085; AAH94085.1; -; mRNA.
DR   RefSeq; NP_001086453.1; NM_001092984.1. [Q52L34-1]
DR   AlphaFoldDB; Q52L34; -.
DR   SMR; Q52L34; -.
DR   BioGRID; 103124; 1.
DR   IntAct; Q52L34; 1.
DR   DNASU; 446264; -.
DR   GeneID; 446264; -.
DR   KEGG; xla:446264; -.
DR   CTD; 446264; -.
DR   Xenbase; XB-GENE-5787620; mthfsd.L.
DR   OrthoDB; 1137978at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 446264; Expressed in ovary and 18 other tissues.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd12270; RRM_MTHFSD; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.40.50.10420; -; 1.
DR   InterPro; IPR002698; FTHF_cligase.
DR   InterPro; IPR024185; FTHF_cligase-like_sf.
DR   InterPro; IPR034359; MTHFSD_RRM.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR13017; PTHR13017; 1.
DR   Pfam; PF01812; 5-FTHF_cyc-lig; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; RNA-binding.
FT   CHAIN           1..415
FT                   /note="Methenyltetrahydrofolate synthase domain-containing
FT                   protein"
FT                   /id="PRO_0000295873"
FT   DOMAIN          311..384
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          252..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         45..82
FT                   /note="ESHQACQNIIDLEVFRRTWEVKVDPDKPLEGVRLAALQ -> GASQACDKLS
FT                   TLKEFQAARIVKINPDTPQKRARFLTLE (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_027119"
SQ   SEQUENCE   415 AA;  46149 MW;  A34AB3F812CF3241 CRC64;
     MEPGIRVDPG CSKWDIRQKV WDYIENNNLA DFPRPVHHRI PNFKESHQAC QNIIDLEVFR
     RTWEVKVDPD KPLEGVRLAA LQARKTLLVP TPRLRTGLFN KITPPPGANK EVLRICSTSQ
     GVKDYSVPMG LDAKVQVDLV VVGSVAVSVQ GWRIGKGEGF ADMEYAMMVS MGAVTEHTVV
     VTVVHDCQVV DIPEELLEDH DLTVDFILTP TRIIKTDCKR AKPQGIIWSM ITREMMGKIP
     ILRNLQDRER RAGKDVSLKD GNASEQGSRQ SPLCLPEKEL GPCGSVLSEH KHLANAQLHT
     KLEACNLHDG ATVYIGDIPS TTRVSELKSM LRERGAAPLR LTWQGAQHRA FLDYRDVAQA
     KQALSSLEGI SINGISLLVE LARTQRPKAN GNQGFRNNKL RATNPSTVSQ PHIPT