MTH_DROYA
ID MTH_DROYA Reviewed; 517 AA.
AC Q9GT50; Q9GT51; Q9GT52; Q9GT53; Q9GT54; Q9GT55; Q9GT56;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=G-protein coupled receptor Mth;
DE AltName: Full=Protein methuselah;
DE Flags: Precursor;
GN Name=mth;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RC STRAIN=BG1013, Yak_2, Yak_23, Yak_30, Yak_4, Yak_5, and Yak_8;
RX PubMed=10995474; DOI=10.1073/pnas.190338897;
RA Schmidt P.S., Duvernell D.D., Eanes W.F.;
RT "Adaptive evolution of a candidate gene for aging in Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:10861-10865(2000).
CC -!- FUNCTION: Involved in biological aging and stress response. Essential
CC for adult survival (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000305}.
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DR EMBL; AF280583; AAG21991.1; -; Genomic_DNA.
DR EMBL; AF280584; AAG21992.1; -; Genomic_DNA.
DR EMBL; AF280585; AAG21993.1; -; Genomic_DNA.
DR EMBL; AF280586; AAG21994.1; -; Genomic_DNA.
DR EMBL; AF280587; AAG21995.1; -; Genomic_DNA.
DR EMBL; AF280588; AAG21996.1; -; Genomic_DNA.
DR EMBL; AF280589; AAG21997.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9GT50; -.
DR SMR; Q9GT50; -.
DR STRING; 7245.FBpp0266036; -.
DR eggNOG; KOG4193; Eukaryota.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
DR CDD; cd00251; Mth_Ecto; 1.
DR Gene3D; 2.170.180.11; -; 1.
DR Gene3D; 2.30.160.11; -; 1.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR044860; Methusela_ecto_dom_1.
DR InterPro; IPR023311; Methusela_ecto_dom_2.
DR InterPro; IPR010596; Methuselah_N_dom.
DR InterPro; IPR036272; Methuselah_N_sf.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF06652; Methuselah_N; 1.
DR SUPFAM; SSF63877; SSF63877; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000250"
FT CHAIN 28..517
FT /note="G-protein coupled receptor Mth"
FT /id="PRO_0000013022"
FT TOPO_DOM 28..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..373
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..457
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 479..517
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 452
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..86
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 88..93
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 97..191
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 98..109
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT DISULFID 153..212
FT /evidence="ECO:0000250|UniProtKB:O97148"
FT VARIANT 11
FT /note="R -> W (in strain: Yak_5)"
FT VARIANT 39
FT /note="D -> N (in strain: Yak_23 and Yak_8)"
FT VARIANT 49
FT /note="G -> E (in strain: Yak_2)"
FT VARIANT 179
FT /note="H -> Y (in strain: Yak_2)"
FT VARIANT 195
FT /note="L -> F (in strain: Yak_5)"
FT VARIANT 227
FT /note="T -> S (in strain: Yak_23)"
FT VARIANT 260
FT /note="L -> H (in strain: Yak_23)"
FT VARIANT 331
FT /note="A -> V (in strain: Yak_2)"
SQ SEQUENCE 517 AA; 59968 MW; 48F2EE02BC27D128 CRC64;
MKLFWVKRLL RISTVVVTLL LLQRTNAAIP DCDYYDTVDI SAAQKLPNGS YLFEGLLVPA
NLTAEYEFTI LPDDSKQKVD KHIRGCVCKL KPCVRFCCPH NHIMDMNVCA GDMTEEELEV
LDPFLNVTLD DGSVVRRHFK KELIVQWDLP MSCDGMFSLD NREKTDQYTL FENGSFFRHH
DRVTLNKREY CLQHLTFVDG NESSIRIAPH NCLISPSRMG QTVVMITSLV CMVLTITVYL
FVKKLQNLHG KCFMCYMVCL FMAYLLLLLN LWQMSQNFCI TAGFLGYFFV MAAFLWLSVI
SLHLWNTFSG SAHNANRFLS EHRFLAYNTY AWGMAVVLTG ITYLADKVVE NEDWNPRMGF
GGHCWICTQS WSAMLYFYGP MVFLIAFNIT MFILTANRII GVKKDIQKFA HRQERKQKLN
SDKQTYTFFL RLFIIMGLTW SLEIGSYISQ FNQTWSNVFL VADYLNWSQG IIIFILFVLK
RSTLRLLMES IRGEGEEVND SEEEISLENT KYDRNVL
