MTL26_HUMAN
ID MTL26_HUMAN Reviewed; 204 AA.
AC Q96S19; A8MTR1; A8MWJ8; A8MZA1; B4DG95; B4DIJ3; D6REA6; F6TF62; F6VM53;
AC Q96IW1; Q96MD6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Methyltransferase-like 26 {ECO:0000312|HGNC:HGNC:14141};
GN Name=METTL26 {ECO:0000312|HGNC:HGNC:14141}; Synonyms=JFP2;
GN ORFNames=C16orf13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
RC TISSUE=Amygdala, Hippocampus, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 1-9; 134-161 AND 181-188, ACETYLATION AT MET-1, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V., Dozynkiewicz M., Norman J.C.;
RL Submitted (JUN-2009) to UniProtKB.
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [8]
RP VARIANT PRO-136.
RX PubMed=20797691; DOI=10.1016/j.ajhg.2010.08.001;
RA Corbett M.A., Bahlo M., Jolly L., Afawi Z., Gardner A.E., Oliver K.L.,
RA Tan S., Coffey A., Mulley J.C., Dibbens L.M., Simri W., Shalata A.,
RA Kivity S., Jackson G.D., Berkovic S.F., Gecz J.;
RT "A focal epilepsy and intellectual disability syndrome is due to a mutation
RT in TBC1D24.";
RL Am. J. Hum. Genet. 87:371-375(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q96S19-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96S19-2; Sequence=VSP_033918;
CC Name=3;
CC IsoId=Q96S19-3; Sequence=VSP_033919;
CC Name=4;
CC IsoId=Q96S19-4; Sequence=VSP_045804;
CC Name=5;
CC IsoId=Q96S19-5; Sequence=VSP_046838;
CC Name=6;
CC IsoId=Q96S19-6; Sequence=VSP_046839;
CC -!- SIMILARITY: Belongs to the UPF0585 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK61238.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAW85785.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK057077; BAB71362.1; -; mRNA.
DR EMBL; AK293046; BAF85735.1; -; mRNA.
DR EMBL; AK294482; BAG57706.1; -; mRNA.
DR EMBL; AK295628; BAG58505.1; -; mRNA.
DR EMBL; AE006464; AAK61238.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z84479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85787.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85785.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471112; EAW85786.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85788.1; -; Genomic_DNA.
DR EMBL; BC007207; AAH07207.1; -; mRNA.
DR EMBL; BC047118; AAH47118.1; -; mRNA.
DR CCDS; CCDS32352.1; -. [Q96S19-3]
DR CCDS; CCDS42090.1; -. [Q96S19-6]
DR CCDS; CCDS42091.1; -. [Q96S19-4]
DR CCDS; CCDS45367.1; -. [Q96S19-5]
DR CCDS; CCDS45368.1; -. [Q96S19-1]
DR RefSeq; NP_001035250.1; NM_001040160.2. [Q96S19-4]
DR RefSeq; NP_001035251.1; NM_001040161.2. [Q96S19-3]
DR RefSeq; NP_001035252.1; NM_001040162.2. [Q96S19-5]
DR RefSeq; NP_001035255.1; NM_001040165.2. [Q96S19-6]
DR RefSeq; NP_115742.3; NM_032366.4. [Q96S19-1]
DR AlphaFoldDB; Q96S19; -.
DR SMR; Q96S19; -.
DR BioGRID; 124050; 8.
DR IntAct; Q96S19; 1.
DR MINT; Q96S19; -.
DR STRING; 9606.ENSP00000440765; -.
DR iPTMnet; Q96S19; -.
DR PhosphoSitePlus; Q96S19; -.
DR BioMuta; METTL26; -.
DR DMDM; 189082900; -.
DR EPD; Q96S19; -.
DR jPOST; Q96S19; -.
DR MassIVE; Q96S19; -.
DR MaxQB; Q96S19; -.
DR PaxDb; Q96S19; -.
DR PeptideAtlas; Q96S19; -.
DR PRIDE; Q96S19; -.
DR ProteomicsDB; 14271; -.
DR ProteomicsDB; 27969; -.
DR ProteomicsDB; 28082; -.
DR ProteomicsDB; 78056; -. [Q96S19-1]
DR ProteomicsDB; 78057; -. [Q96S19-2]
DR ProteomicsDB; 78058; -. [Q96S19-3]
DR Antibodypedia; 51680; 71 antibodies from 17 providers.
DR DNASU; 84326; -.
DR Ensembl; ENST00000301686.13; ENSP00000445926.2; ENSG00000130731.16. [Q96S19-1]
DR Ensembl; ENST00000338401.8; ENSP00000444140.2; ENSG00000130731.16. [Q96S19-3]
DR Ensembl; ENST00000397664.8; ENSP00000440475.2; ENSG00000130731.16. [Q96S19-5]
DR Ensembl; ENST00000397665.6; ENSP00000444460.2; ENSG00000130731.16. [Q96S19-6]
DR Ensembl; ENST00000397666.6; ENSP00000440765.2; ENSG00000130731.16. [Q96S19-4]
DR GeneID; 84326; -.
DR KEGG; hsa:84326; -.
DR MANE-Select; ENST00000301686.13; ENSP00000445926.2; NM_032366.5; NP_115742.3.
DR UCSC; uc002chv.3; human. [Q96S19-1]
DR CTD; 84326; -.
DR GeneCards; METTL26; -.
DR HGNC; HGNC:14141; METTL26.
DR HPA; ENSG00000130731; Low tissue specificity.
DR neXtProt; NX_Q96S19; -.
DR OpenTargets; ENSG00000130731; -.
DR PharmGKB; PA25526; -.
DR VEuPathDB; HostDB:ENSG00000130731; -.
DR eggNOG; ENOG502SNXQ; Eukaryota.
DR GeneTree; ENSGT00390000010750; -.
DR HOGENOM; CLU_067698_2_0_1; -.
DR InParanoid; Q96S19; -.
DR OMA; NPEWGVR; -.
DR OrthoDB; 1359763at2759; -.
DR PhylomeDB; Q96S19; -.
DR TreeFam; TF315025; -.
DR PathwayCommons; Q96S19; -.
DR SignaLink; Q96S19; -.
DR BioGRID-ORCS; 84326; 7 hits in 1046 CRISPR screens.
DR GeneWiki; Chromosome_16_open_reading_frame_13; -.
DR GenomeRNAi; 84326; -.
DR Pharos; Q96S19; Tdark.
DR PRO; PR:Q96S19; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96S19; protein.
DR Bgee; ENSG00000130731; Expressed in apex of heart and 176 other tissues.
DR ExpressionAtlas; Q96S19; baseline and differential.
DR Genevisible; Q96S19; HS.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR010342; DUF938.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR20974; PTHR20974; 1.
DR Pfam; PF06080; DUF938; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Direct protein sequencing;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..204
FT /note="Methyltransferase-like 26"
FT /id="PRO_0000337114"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000269|Ref.6, ECO:0007744|PubMed:22814378"
FT MOD_RES 149
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9DCS2"
FT VAR_SEQ 66..204
FT /note="SIAATTQAQGLTNVKAPLHLDVTWGWEHWGGILPQSLDLLLCINMAHVSPLR
FT CTEGLFRAAGHLLKPRALLITYGPYAINGKISPQSNVDFDLMLRCRNPEWGLRDTALLE
FT DLGKASGLLLERMVDMPANNKCLIFRKN -> RCGPRGGHFYRCGGPGPQEPTARSPGG
FT KGCGSGSEGAGWEPGGAPGAGPSCAAPAAAEVGGPRGPPSQPLWSPLLNVPPSLP (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033918"
FT VAR_SEQ 66..163
FT /note="SIAATTQAQGLTNVKAPLHLDVTWGWEHWGGILPQSLDLLLCINMAHVSPLR
FT CTEGLFRAAGHLLKPRALLITYGPYAINGKISPQSNVDFDLMLRCR -> RGSSEQQDT
FT CSNPGPCSSPTG (in isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_046838"
FT VAR_SEQ 66..162
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033919"
FT VAR_SEQ 121..204
FT /note="GLFRAAGHLLKPRALLITYGPYAINGKISPQSNVDFDLMLRCRNPEWGLRDT
FT ALLEDLGKASGLLLERMVDMPANNKCLIFRKN -> EPRMGASGHSPPGGPGKGQWPAP
FT GEDGGHASQQQMPDLPEKLSPSFTPAHLHPCRRLCEARTLPP (in isoform 6)"
FT /evidence="ECO:0000305"
FT /id="VSP_046839"
FT VAR_SEQ 141..204
FT /note="PYAINGKISPQSNVDFDLMLRCRNPEWGLRDTALLEDLGKASGLLLERMVDM
FT PANNKCLIFRKN -> EPRMGASGHSPPGGPGKGQWPAPGEDGGHASQQQMPDLPEKLS
FT PSFTPAHLHPCRRLCEARTLPP (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045804"
FT VARIANT 136
FT /note="L -> P (in dbSNP:rs865791888)"
FT /evidence="ECO:0000269|PubMed:20797691"
FT /id="VAR_064368"
FT CONFLICT Q96S19-4:196
FT /note="R -> G (in Ref. 1; BAG58505)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 22578 MW; D927CBB1151FC753 CRC64;
MLVAAAAERN KDPILHVLRQ YLDPAQRGVR VLEVASGSGQ HAAHFARAFP LAEWQPSDVD
QRCLDSIAAT TQAQGLTNVK APLHLDVTWG WEHWGGILPQ SLDLLLCINM AHVSPLRCTE
GLFRAAGHLL KPRALLITYG PYAINGKISP QSNVDFDLML RCRNPEWGLR DTALLEDLGK
ASGLLLERMV DMPANNKCLI FRKN
