MTL26_MOUSE
ID MTL26_MOUSE Reviewed; 204 AA.
AC Q9DCS2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Methyltransferase-like 26 {ECO:0000312|MGI:MGI:1915597};
GN Name=Mettl26 {ECO:0000312|MGI:MGI:1915597};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the UPF0585 family. {ECO:0000305}.
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DR EMBL; AK002535; BAB22171.1; -; mRNA.
DR EMBL; AK151352; BAE30328.1; -; mRNA.
DR EMBL; AK170337; BAE41727.1; -; mRNA.
DR EMBL; BC069266; AAH69266.1; -; mRNA.
DR CCDS; CCDS28536.1; -.
DR RefSeq; NP_080962.1; NM_026686.2.
DR AlphaFoldDB; Q9DCS2; -.
DR SMR; Q9DCS2; -.
DR STRING; 10090.ENSMUSP00000026827; -.
DR iPTMnet; Q9DCS2; -.
DR PhosphoSitePlus; Q9DCS2; -.
DR EPD; Q9DCS2; -.
DR jPOST; Q9DCS2; -.
DR MaxQB; Q9DCS2; -.
DR PaxDb; Q9DCS2; -.
DR PeptideAtlas; Q9DCS2; -.
DR PRIDE; Q9DCS2; -.
DR ProteomicsDB; 287635; -.
DR Antibodypedia; 51680; 71 antibodies from 17 providers.
DR Ensembl; ENSMUST00000026827; ENSMUSP00000026827; ENSMUSG00000025731.
DR GeneID; 68347; -.
DR KEGG; mmu:68347; -.
DR UCSC; uc008bcl.2; mouse.
DR CTD; 84326; -.
DR MGI; MGI:1915597; Mettl26.
DR VEuPathDB; HostDB:ENSMUSG00000025731; -.
DR eggNOG; ENOG502QVX9; Eukaryota.
DR GeneTree; ENSGT00390000010750; -.
DR HOGENOM; CLU_067698_2_0_1; -.
DR InParanoid; Q9DCS2; -.
DR OMA; NPEWGVR; -.
DR OrthoDB; 1359763at2759; -.
DR PhylomeDB; Q9DCS2; -.
DR TreeFam; TF315025; -.
DR BioGRID-ORCS; 68347; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Mettl26; mouse.
DR PRO; PR:Q9DCS2; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9DCS2; protein.
DR Bgee; ENSMUSG00000025731; Expressed in right kidney and 236 other tissues.
DR ExpressionAtlas; Q9DCS2; baseline and differential.
DR Genevisible; Q9DCS2; MM.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR010342; DUF938.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR20974; PTHR20974; 1.
DR Pfam; PF06080; DUF938; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..204
FT /note="Methyltransferase-like 26"
FT /id="PRO_0000337115"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96S19"
FT MOD_RES 149
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 204 AA; 22687 MW; 494D8B329AD1EAD0 CRC64;
MMMAAAAERN KEPILSVLRQ YVDPAQRCVR VLEVASGSGQ HAAHFAQAFP NAEWQPSDVD
QRCLDSIAAT TRAQGLSNVK APLYLDVTWE WEQWGGIPPR SLDLLLCINM IHISPLNCTE
GLFRAAGHLL KTKAVLITYG PYAVNGKISP QSNVDFDLTL RCRNPEWGLR DTVLLEELGQ
ASGLVLERMV DMPANNKCLI FRKE
