MTL26_RAT
ID MTL26_RAT Reviewed; 204 AA.
AC Q497C3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Methyltransferase-like 26 {ECO:0000312|RGD:1307155};
GN Name=Mettl26 {ECO:0000312|RGD:1307155};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q497C3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q497C3-2; Sequence=VSP_033920;
CC -!- SIMILARITY: Belongs to the UPF0585 family. {ECO:0000305}.
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DR EMBL; AABR03073234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100622; AAI00623.1; -; mRNA.
DR RefSeq; NP_001032265.1; NM_001037188.1. [Q497C3-2]
DR RefSeq; XP_006246028.1; XM_006245966.3. [Q497C3-1]
DR RefSeq; XP_017452720.1; XM_017597231.1. [Q497C3-2]
DR AlphaFoldDB; Q497C3; -.
DR SMR; Q497C3; -.
DR IntAct; Q497C3; 1.
DR STRING; 10116.ENSRNOP00000036902; -.
DR iPTMnet; Q497C3; -.
DR PhosphoSitePlus; Q497C3; -.
DR jPOST; Q497C3; -.
DR PaxDb; Q497C3; -.
DR Ensembl; ENSRNOT00000037372; ENSRNOP00000029827; ENSRNOG00000021615. [Q497C3-2]
DR Ensembl; ENSRNOT00000037381; ENSRNOP00000036902; ENSRNOG00000021615. [Q497C3-1]
DR GeneID; 302998; -.
DR KEGG; rno:302998; -.
DR UCSC; RGD:1307155; rat. [Q497C3-1]
DR CTD; 84326; -.
DR RGD; 1307155; Mettl26.
DR eggNOG; ENOG502QVX9; Eukaryota.
DR GeneTree; ENSGT00390000010750; -.
DR HOGENOM; CLU_067698_0_0_1; -.
DR InParanoid; Q497C3; -.
DR OMA; NPEWGVR; -.
DR OrthoDB; 1359763at2759; -.
DR PhylomeDB; Q497C3; -.
DR TreeFam; TF315025; -.
DR PRO; PR:Q497C3; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000021615; Expressed in ovary and 19 other tissues.
DR Genevisible; Q497C3; RN.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR010342; DUF938.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR20974; PTHR20974; 1.
DR Pfam; PF06080; DUF938; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..204
FT /note="Methyltransferase-like 26"
FT /id="PRO_0000337116"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96S19"
FT MOD_RES 149
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9DCS2"
FT VAR_SEQ 164..204
FT /note="NPEWGLRDTALLEELGQASGLTLERMVDMPANNKCLIFRKE -> FSRHGGQ
FT RRKKRRGKMGTGRRKLNCHF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033920"
SQ SEQUENCE 204 AA; 22612 MW; DA4199486AA382B1 CRC64;
MMVAAAAERN KEPILCVLRQ YVDPAQRGVR VLEVASGSGQ HAAHFARAFP NAEWQPSDVD
QRCLDSIAAT TQAQGLSNVK APLYLDVTWK WEQWGGIPPR SLDLLLCINM IHISPLNCTE
GLFRAAGHLL KTKAVLITYG PYAINGKISP QSNVDFDLTL RCRNPEWGLR DTALLEELGQ
ASGLTLERMV DMPANNKCLI FRKE
