MTL32_CANGA
ID MTL32_CANGA Reviewed; 210 AA.
AC Q870I4; Q6FX73;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Mating-type-like protein ALPHA2, silenced copy at MTL3;
DE AltName: Full=MTL3alpha2 protein;
GN Name=MTL3alpha2; OrderedLocusNames=CAGL0B00264g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=7549;
RX PubMed=12684382; DOI=10.1128/ec.2.2.328-340.2003;
RA Srikantha T., Lachke S.A., Soll D.R.;
RT "Three mating type-like loci in Candida glabrata.";
RL Eukaryot. Cell 2:328-340(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC proteins that act as master switches in yeast differentiation by
CC controlling gene expression in a cell type-specific fashion.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC C.glabrata. MTL1 seems to be the expression locus that determines the
CC mating type of the cell, whereas MTL2 (containing MTL2A1) and MTL3
CC (containing MTL3ALPHA1 and MTL3ALPHA2) appear to represent silenced
CC repositories of mating type information. Notably, MTL3ALPHA2 contains a
CC unique stretch coding for 22 amino acids at the C-terminus that is not
CC shared by MTL1ALPHA2.
CC -!- MISCELLANEOUS: Haploid C.glabrata strains can switch mating type,
CC however, neither mating nor diploid forms of C.glabrata have been
CC observed so far.
CC -!- SIMILARITY: Belongs to the TALE/M-ATYP homeobox family. {ECO:0000305}.
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DR EMBL; AY207368; AAP06786.1; -; Genomic_DNA.
DR EMBL; CR380948; CAG57881.1; -; Genomic_DNA.
DR RefSeq; XP_444981.1; XM_444981.1.
DR AlphaFoldDB; Q870I4; -.
DR SMR; Q870I4; -.
DR STRING; 5478.XP_444981.1; -.
DR EnsemblFungi; CAG57881; CAG57881; CAGL0B00264g.
DR GeneID; 2886554; -.
DR KEGG; cgr:CAGL0B00264g; -.
DR CGD; CAL0127028; MTLalpha2.
DR VEuPathDB; FungiDB:CAGL0B00264g; -.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_091806_1_0_1; -.
DR InParanoid; Q870I4; -.
DR OMA; IYISLFD; -.
DR Proteomes; UP000002428; Chromosome B.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..210
FT /note="Mating-type-like protein ALPHA2, silenced copy at
FT MTL3"
FT /id="PRO_0000049176"
FT DNA_BIND 108..170
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 210 AA; 24663 MW; C55E6A9A93192BCC CRC64;
MSKKSRISIT HLLNPIQEEN LKEKLQEINN QLISLCSSLP KRQSLPGPSS DILRFLSRNN
LDPQEIGLIK TTYRLSTLLS KLREHEIVFN VVTKDHLLKK GVPNHYAASY RGHRFTRENV
QILETWYRNH IDNPYLDHNS QQYLAQKTNL SKIQIKNWVA NRRRKQKSIY ISLFDIHNIE
SGEYAYIEKV CYIIIIICHL FLVFSLSCLT