ID   MTL5_RAT                Reviewed;         475 AA.
AC   Q5XHX9;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Tesmin;
DE   AltName: Full=Metallothionein-like 5, testis-specific;
GN   Name=Tesmin {ECO:0000312|RGD:1309788}; Synonyms=Mtl5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34 AND SER-67, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: May have a role in spermatogenesis. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9WTJ6}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9WTJ6}. Note=Predominantly localized to the
CC       cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M
CC       transition upon treatment with cadmium, cobalt or zinc.
CC       {ECO:0000250|UniProtKB:Q9WTJ6}.
CC   -!- SIMILARITY: Belongs to the lin-54 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH83920.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC083920; AAH83920.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001012069.2; NM_001012069.2.
DR   AlphaFoldDB; Q5XHX9; -.
DR   SMR; Q5XHX9; -.
DR   STRING; 10116.ENSRNOP00000019861; -.
DR   iPTMnet; Q5XHX9; -.
DR   PhosphoSitePlus; Q5XHX9; -.
DR   PaxDb; Q5XHX9; -.
DR   Ensembl; ENSRNOT00000019861; ENSRNOP00000019861; ENSRNOG00000014671.
DR   GeneID; 309142; -.
DR   KEGG; rno:309142; -.
DR   UCSC; RGD:1309788; rat.
DR   CTD; 9633; -.
DR   RGD; 1309788; Tesmin.
DR   eggNOG; KOG1171; Eukaryota.
DR   GeneTree; ENSGT00940000161379; -.
DR   HOGENOM; CLU_025199_0_0_1; -.
DR   InParanoid; Q5XHX9; -.
DR   OMA; ILRIEFK; -.
DR   OrthoDB; 389707at2759; -.
DR   PhylomeDB; Q5XHX9; -.
DR   TreeFam; TF313189; -.
DR   PRO; PR:Q5XHX9; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000014671; Expressed in testis and 1 other tissue.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007140; P:male meiotic nuclear division; ISO:RGD.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR   InterPro; IPR005172; CRC.
DR   InterPro; IPR028307; Lin-54_fam.
DR   InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR   PANTHER; PTHR12446; PTHR12446; 1.
DR   Pfam; PF03638; TCR; 1.
DR   SMART; SM01114; CXC; 1.
DR   PROSITE; PS51634; CRC; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Differentiation; Nucleus; Phosphoprotein;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..475
FT                   /note="Tesmin"
FT                   /id="PRO_0000349273"
FT   DOMAIN          263..372
FT                   /note="CRC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00971"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         67
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   475 AA;  50469 MW;  FBB0DFBB345DA6A8 CRC64;
     MEDALLGAMT GPEDELGAEL FGSERAFADG LALSPAGGAA DRDELPVLAD AYLGATEPGE
     PLLRALSPPP GAEVPAALLG DFPGLPELRS SDDAAPPPAY SVHVLSSLLP GARGPALLPL
     SAGVRVIPVE IKEAGGGVPG SSPEDAAFQA PLAQESCCKF SSSQEAEEAS GCPRKKDSSP
     MVICQLKGGA QMLCIDNCGA RELKALHLLP QYDDQSSFPQ SELPKPMTTL VGRLLPVPAK
     LNLITQVDNG ALPSAVNGAA FPSGPALQGP PKIALAGYCD CFSSGDFCNS CSCNNLRHEL
     ERFKAIKACL DRNPEAFQPK MGKGRLGAAK LRHSKGCNCK RSGCLKNYCE CYEAKITCSS
     ICKCIACKNY EESPERKMLM STPHYMEPGD FESSHHLSPA KFSGPPRLRK NRQAFSCISW
     EVVEATCACL LAQGEEAEQE RCSPSLAEQM VLEEFGRCLS QILHIEFKSK GLKIE