ID   MTLD_GEOSE              Reviewed;         382 AA.
AC   Q45421;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase;
DE            EC=1.1.1.17;
GN   Name=mtlD;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29609 / DSM 2027 / NCA 1503 / NCIMB 8924;
RX   PubMed=8824601; DOI=10.1128/jb.178.19.5586-5591.1996;
RA   Henstra S.A., Tolner B., ten Hoeve Duurkens R.H., Konings W.N.,
RA   Robillard G.T.;
RT   "Cloning, expression, and isolation of the mannitol transport protein from
RT   the thermophilic bacterium Bacillus stearothermophilus.";
RL   J. Bacteriol. 178:5586-5591(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate
CC         + H(+) + NADH; Xref=Rhea:RHEA:19661, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57634, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:61381; EC=1.1.1.17;
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; U18943; AAC44466.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q45421; -.
DR   SMR; Q45421; -.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019594; P:mannitol metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   HAMAP; MF_00196; Mannitol_dehydrog; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR023028; Mannitol_1_phos_5_DH.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR023027; Mannitol_DH_CS.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..382
FT                   /note="Mannitol-1-phosphate 5-dehydrogenase"
FT                   /id="PRO_0000170697"
FT   BINDING         3..14
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   382 AA;  43168 MW;  6A60B887A8C20052 CRC64;
     MLAVHFGAGN IGRGFIGSLL SQSGYEVVFV DINDELVRLL KEKQEYRVII ADENRQELLI
     RNVSAVNSQT EREKVIDYIT KAHLITTAVG PHILPAIATI LAEGLQKRIT INKTPLHIIA
     CENMIGGSDV LKSHVFEKIS EADKPLFEKY YGFLNCAVDR IVPNQKHDDP LSVVVEPFFE
     WVIEKRNIIG AIPPIQGAHF VDDLKPYIER KLFTVNTGHA IASYLGYYKK LQTIQEAMCD
     QEIRSDVEKA LHESGAVLVK KYGWNENEHQ SYIQKIIQRF INPSISDEVV RVARSPIRKL
     GANDRLIGPA TQYYDLFGQV PHGLVKGIAA LLLFDYENDE EAVALQKTIQ ETGVEGALYQ
     YSQLEKDHPL VIAIKDQWQH LK