ID   MTLR_ECOL6              Reviewed;         195 AA.
AC   P0AF11; P36563;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Mannitol operon repressor {ECO:0000312|EMBL:AAN82854.1};
DE   AltName: Full=Mannitol repressor protein {ECO:0000250|UniProtKB:P0AF10};
GN   Name=mtlR {ECO:0000312|EMBL:AAN82854.1}; OrderedLocusNames=c4418;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Involved in the repression of the expression of the mannitol
CC       mtlADR operon. Does not bind the operator/promoter regulatory region of
CC       this operon. Therefore, seems to belong to a new class of transcription
CC       factors in bacteria that may regulate gene expression indirectly,
CC       perhaps as a part of a larger transcriptional complex.
CC       {ECO:0000250|UniProtKB:P0AF10}.
CC   -!- SUBUNIT: Homodimer. Can also form higher level multimer aggregates.
CC       {ECO:0000250|UniProtKB:P0AF10}.
CC   -!- SIMILARITY: Belongs to the MtlR/FumE family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN82854.1; -; Genomic_DNA.
DR   RefSeq; WP_000228269.1; NC_004431.1.
DR   AlphaFoldDB; P0AF11; -.
DR   SMR; P0AF11; -.
DR   STRING; 199310.c4418; -.
DR   EnsemblBacteria; AAN82854; AAN82854; c4418.
DR   GeneID; 58389551; -.
DR   KEGG; ecc:c4418; -.
DR   eggNOG; COG3722; Bacteria.
DR   HOGENOM; CLU_099448_0_0_6; -.
DR   OMA; KMGMVQL; -.
DR   BioCyc; ECOL199310:C4418-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   InterPro; IPR007761; MtlR-like.
DR   InterPro; IPR038026; MtlR-like_sf.
DR   PANTHER; PTHR37941; PTHR37941; 1.
DR   Pfam; PF05068; MtlR; 1.
DR   SUPFAM; SSF158668; SSF158668; 1.
PE   3: Inferred from homology;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..195
FT                   /note="Mannitol operon repressor"
FT                   /id="PRO_0000096629"
SQ   SEQUENCE   195 AA;  21990 MW;  0BB49156ACF44354 CRC64;
     MVDQAQDTLR PNNRLSDMQA TMEQTQAFEN RVLERLNAGK TVRSFLITAV ELLTEAVNLL
     VLQVFRKDDY AVKYAVEPLL DGDGPLGDLS VRLKLIYGLG VINRQEYEDA ELLMALREEL
     NHDGNEYAFT DDEILGPFGE LHCVAALPPP PQFEPADSSL YAMQIQRYQQ AVRSTMVLSL
     TELISKISLK KAFQK