MTM1_ARATH
ID MTM1_ARATH Reviewed; 413 AA.
AC Q944H5; Q9SUE4;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Mitochondrial carrier protein MTM1;
DE AltName: Full=Manganese tracking factor for mitochondrial SOD2;
GN Name=MTM1; OrderedLocusNames=At4g27940; ORFNames=T13J8.50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=15003237; DOI=10.1016/j.tplants.2004.01.007;
RA Picault N., Hodges M., Palmieri L., Palmieri F.;
RT "The growing family of mitochondrial carriers in Arabidopsis.";
RL Trends Plant Sci. 9:138-146(2004).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY PARAQUAT, AND TISSUE
RP SPECIFICITY.
RX PubMed=17522887; DOI=10.1007/s00425-007-0547-6;
RA Su Z., Chai M.F., Lu P.L., An R., Chen J., Wang X.C.;
RT "AtMTM1, a novel mitochondrial protein, may be involved in activation of
RT the manganese-containing superoxide dismutase in Arabidopsis.";
RL Planta 226:1031-1039(2007).
CC -!- FUNCTION: Involved in the mitochondrial activation of MSD1 by
CC specifically facilitating insertion of the essential manganese
CC cofactor. Has the ability to activate iron regulon in an iron-dependent
CC manner. {ECO:0000269|PubMed:17522887}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:17522887}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17522887}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:17522887}.
CC -!- INDUCTION: By paraquat (methyl viologen).
CC {ECO:0000269|PubMed:17522887}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB36763.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79596.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL035524; CAB36763.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161572; CAB79596.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85411.1; -; Genomic_DNA.
DR EMBL; AF428433; AAL16202.1; -; mRNA.
DR EMBL; AY125549; AAM78059.1; -; mRNA.
DR EMBL; AY085360; AAM62590.1; -; mRNA.
DR PIR; T02895; T02895.
DR RefSeq; NP_567790.1; NM_118932.5.
DR AlphaFoldDB; Q944H5; -.
DR SMR; Q944H5; -.
DR BioGRID; 14194; 1.
DR STRING; 3702.AT4G27940.1; -.
DR PaxDb; Q944H5; -.
DR PRIDE; Q944H5; -.
DR ProteomicsDB; 250909; -.
DR EnsemblPlants; AT4G27940.1; AT4G27940.1; AT4G27940.
DR GeneID; 828907; -.
DR Gramene; AT4G27940.1; AT4G27940.1; AT4G27940.
DR KEGG; ath:AT4G27940; -.
DR Araport; AT4G27940; -.
DR TAIR; locus:2132947; AT4G27940.
DR eggNOG; KOG0761; Eukaryota.
DR HOGENOM; CLU_015166_0_1_1; -.
DR InParanoid; Q944H5; -.
DR OMA; YWWGYES; -.
DR OrthoDB; 1007936at2759; -.
DR PhylomeDB; Q944H5; -.
DR PRO; PR:Q944H5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q944H5; baseline and differential.
DR Genevisible; Q944H5; AT.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0016530; F:metallochaperone activity; IGI:UniProtKB.
DR GO; GO:0004784; F:superoxide dismutase activity; IDA:TAIR.
DR GO; GO:0006828; P:manganese ion transport; ISS:UniProtKB.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR GO; GO:1901562; P:response to paraquat; IEP:UniProtKB.
DR GO; GO:0097501; P:stress response to metal ion; IEP:TAIR.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR045315; Mtm1-like.
DR PANTHER; PTHR45760; PTHR45760; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..413
FT /note="Mitochondrial carrier protein MTM1"
FT /id="PRO_0000421269"
FT TRANSMEM 65..85
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..226
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..399
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 59..193
FT /note="Solcar 1"
FT REPEAT 205..305
FT /note="Solcar 2"
FT REPEAT 318..406
FT /note="Solcar 3"
SQ SEQUENCE 413 AA; 44534 MW; 2A5F7275774A8D97 CRC64;
MVEAERAENS WIASETSPSS SPVVIESSDF SITDGMRDVS GFGIASRPQL DKGLSENNIG
FTERVFSAAG AAVLSAVTLN PLDVVKTRLQ AQAAGMSYSH PLSNSIGRMA FFGPNMMFAD
LRCSPSCARA GVEGTVSICP PDCFQYKGTF DVFTKIIRQE GLGRLWRGTN AGLALAVPMV
GIYLPFYDMF RNRLEELSRE KAPAMTFCVP TVAGSLARSL ACTVCYPIDL ARTRMQAFKE
AKAGVKPPGV FKTLVGVFSE VRTANNLESS LHNYRGLWRG LGAQLARDVP FSAICWSTLE
PIKKRLLGVA GNDTNLVGVF GATFSAGFIA GSIAAAATCP LDVARTRRQI EKDPGRALMM
TTRQTLIEVW RDGGMRGLFM GMGPRVARAG PSVGIVVSFY EVVKYVLHRH ASS
