ID   MTMB1_METAC             Reviewed;         458 AA.
AC   P58865;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 3.
DT   23-FEB-2022, entry version 89.
DE   RecName: Full=Monomethylamine methyltransferase MtmB1;
DE            Short=MMA methyltransferase 1;
DE            Short=MMAMT 1;
DE            EC=2.1.1.248;
GN   Name=mtmB1; OrderedLocusNames=MA_0144;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- FUNCTION: Catalyzes the transfer of the methyl group from
CC       monomethylamine to the corrinoid cofactor of MtmC. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co(I)-[methylamine-specific corrinoid protein] + H(+) +
CC         methylamine = methyl-Co(III)-[methylamine-specific corrinoid protein]
CC         + NH4(+); Xref=Rhea:RHEA:26059, Rhea:RHEA-COMP:11120, Rhea:RHEA-
CC         COMP:11121, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:59338,
CC         ChEBI:CHEBI:85033, ChEBI:CHEBI:85035; EC=2.1.1.248;
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from methylamine.
CC   -!- SUBUNIT: Can form a complex with MtmC. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the monomethylamine methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AE010299; AAM03597.1; -; Genomic_DNA.
DR   STRING; 188937.MA_0144; -.
DR   KEGG; mac:MA_0144; -.
DR   HOGENOM; CLU_047925_0_0_2; -.
DR   OMA; QDKTTGM; -.
DR   UniPathway; UPA00643; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0043852; F:monomethylamine methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.460; -; 1.
DR   InterPro; IPR008031; MtmB_MeTrfase.
DR   InterPro; IPR036655; MtmB_sf.
DR   Pfam; PF05369; MtmB; 1.
DR   SUPFAM; SSF75098; SSF75098; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Methyltransferase; Pyrrolysine; Reference proteome;
KW   Transferase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..458
FT                   /note="Monomethylamine methyltransferase MtmB1"
FT                   /id="PRO_0000216555"
FT   NON_STD         202
FT                   /note="Pyrrolysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   458 AA;  50378 MW;  F6ACF39C148B1882 CRC64;
     MTFRKSFDCY DFYDRAKVGE KCTQDDWDLM KIPMKAMELK QKYGLDFKGE FVPTDRDMME
     KLFQAGFEML LECGIYCTDT HRIVKYTEDE IWDAINNVQK EFTLGTGRDA VNVRKRSVGD
     KRKPIVQGGP TGSPISEDVF MPVHMSYALE KEVDTIVDGV MTSVRGKPPV PKSPYEVLAA
     KTEARLIKQA CAMAGRPGMG IOGPETSLSA QGNISSDCVG GQISSDSHEV SQLNELKIDL
     DAIAVIAHYK GNSDIIMDEQ MPIFGGYAGG IEETTIVDVA THINAFVMSS ASWHLDGPVH
     IRWGSTNTRE TLTIAGWACA TISEFTDILS GNQYYPCAGP CTEMCLLEAS AQSITDTASG
     REILSGVASA KGVVTDKTTG MEARMMGEVA RATAGVEISE INKILDKLVA LYEKNYANAP
     AGKTFQECYD VKTVTPTEEY MHVYDGARKK LEDLGLVF