ID   MTMB1_METBF             Reviewed;         458 AA.
AC   Q46E72; Q46E73;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 4.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Monomethylamine methyltransferase MtmB1;
DE            Short=MMA methyltransferase 1;
DE            Short=MMAMT 1;
DE            EC=2.1.1.248;
GN   Name=mtmB1; OrderedLocusNames=Mbar_A0843;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
RN   [2]
RP   SEQUENCE REVISION.
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goodwin L.A., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Anderson I., Richardson P.;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the transfer of the methyl group from
CC       monomethylamine to the corrinoid cofactor of MtmC. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co(I)-[methylamine-specific corrinoid protein] + H(+) +
CC         methylamine = methyl-Co(III)-[methylamine-specific corrinoid protein]
CC         + NH4(+); Xref=Rhea:RHEA:26059, Rhea:RHEA-COMP:11120, Rhea:RHEA-
CC         COMP:11121, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:59338,
CC         ChEBI:CHEBI:85033, ChEBI:CHEBI:85035; EC=2.1.1.248;
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from methylamine.
CC   -!- SIMILARITY: Belongs to the monomethylamine methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000099; AAZ69819.4; -; Genomic_DNA.
DR   STRING; 269797.Mbar_A0843; -.
DR   KEGG; mba:Mbar_A0843; -.
DR   eggNOG; arCOG05143; Archaea.
DR   HOGENOM; CLU_047925_0_0_2; -.
DR   UniPathway; UPA00643; -.
DR   GO; GO:0043852; F:monomethylamine methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.460; -; 1.
DR   InterPro; IPR008031; MtmB_MeTrfase.
DR   InterPro; IPR036655; MtmB_sf.
DR   Pfam; PF05369; MtmB; 1.
DR   SUPFAM; SSF75098; SSF75098; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Methyltransferase; Pyrrolysine; Transferase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..458
FT                   /note="Monomethylamine methyltransferase MtmB1"
FT                   /id="PRO_0000216552"
FT   NON_STD         202
FT                   /note="Pyrrolysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   458 AA;  50104 MW;  B3512DDBA22693B7 CRC64;
     MTFRKSFDCY DFYDRAKVGE KCTQDDWDLM KIPMKAMELK QKYGLDFKGE FIPTDKDMME
     KLFKAGFEML LECGIYCTDT HRIVKYTEDE IWDAINNVQK EFVLGTGRDA VNVKKRSVGD
     KAKPIVQGGP TGSPISEDVF MPVHMSYALE KEVDTIVNGV MTSVRGKAPV PKSPYEVLAA
     KTETRLIKNA CAMAGRPGMG VOGPETSLSA QGNISADCAG GMTCTDSHEV SQLNELKIDL
     DAISVIAHYK GNSDIIMDEQ MPIFGGYAGG IEETTIVDVA THINAVIMSS ASWHLDGPVH
     IRWGSTNTRE TLTIAGWACA TISEFTDILS GNQYYPCAGP CTEMCLLEAS AQSITDTASG
     REILSGVASA KGVVTDKTTG MEARMMGEVA RATAGVEISE VNVILDKLVA LYEKNYASAP
     AGKTFQECYD VKTVTPTEEY MQVYDGARKK LEDLGLVF