ID   MTMRA_DANRE             Reviewed;         752 AA.
AC   A0JMF6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Myotubularin-related protein 10;
DE   AltName: Full=Inactive phosphatidylinositol 3-phosphatase 10 {ECO:0000305};
GN   Name=mtmr10; ORFNames=zgc:153233;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000305}.
CC   -!- CAUTION: Although it belongs to the non-receptor class myotubularin
CC       subfamily, lacks the conserved active site cysteine residue at position
CC       388 in the dsPTPase catalytic loop, suggesting that it has no
CC       phosphatase activity. {ECO:0000305}.
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DR   EMBL; BC125860; AAI25861.1; -; mRNA.
DR   AlphaFoldDB; A0JMF6; -.
DR   SMR; A0JMF6; -.
DR   STRING; 7955.ENSDARP00000109082; -.
DR   PaxDb; A0JMF6; -.
DR   PeptideAtlas; A0JMF6; -.
DR   PRIDE; A0JMF6; -.
DR   ZFIN; ZDB-GENE-061103-52; mtmr10.
DR   eggNOG; KOG1089; Eukaryota.
DR   InParanoid; A0JMF6; -.
DR   PhylomeDB; A0JMF6; -.
DR   PRO; PR:A0JMF6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR   CDD; cd13346; PH-GRAM_MTMR10; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR030573; MTMR10.
DR   InterPro; IPR036004; MTMR10_PH-GRAM.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; PTHR10807; 1.
DR   PANTHER; PTHR10807:SF39; PTHR10807:SF39; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 2.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..752
FT                   /note="Myotubularin-related protein 10"
FT                   /id="PRO_0000284362"
FT   DOMAIN          206..636
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00669"
FT   COILED          652..683
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   752 AA;  85595 MW;  2005FBC5FA2A048A CRC64;
     MFSGKQTKPT FKSYLPPLQT DLKKSPQLPI KKLEAKLLPG EIVVNEANFV RKCIGADSGQ
     DDLWGKLVCT NFKVSFISHN SLPQQRFQCT HRLLGEHDIP LACVEQVVTV NDVKGKQKIL
     GSNQKLKFNP TELILYCKDF RIIRFRFDEA GPESAKKVCL AIAHYSHPAD PQLLFGFEYV
     GKRYHGSAGE RVNGVDPGGG LQTPLFDCSS DWDREIKRTG ASEWRVCTIN QGYFISPSLP
     EFFVVPVSLA DQDLKQYACC FYSQRIPLWC WNHPSGSALV RMSNISDPQQ QRKVEQRISS
     AITKSHPLRS DVFKSDLDKN LPNIQDIQAA LLKLRQICVI ESFEESEEKW LSSLESSRWM
     EYVRTFLRHA VEVVYMLESR HVSVILLEKE DRDLSCVISS LVQLMCDPHC RSLHGFQALI
     QKEWVMAGHR FLDRCNHLKK SDKEELWNQY PAAFEFTEVY LTVLGDSMWV PVFSTFLFNC
     PRQRAEHSRD FASSKSIHLG QDQALRFPPV WDWSQQFSLK DQTLFNNPLY VGKIATCLQN
     GTVKTFTHRR SKKNYSSTVR GLPSLMRNGS LGPNDTLTRR NSLVLRLRSD LSQVREQPET
     PSERFVRDFF SRAVDLQGLL LPQLLPSHLS VWKLYFLRWV PEAQIPHGGP VTAFHKLSVL
     TDEIEMLQNQ LRQYKGAAGT ANTSHAEHSK MYFKATSTPQ QCPAPPGYLS SSFPFSPVGN
     LCRPGILGTP LSKFLNGAKI WLSTETLANE TI