ID   MTMRA_MOUSE             Reviewed;         771 AA.
AC   Q7TPM9; Q6PE99;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Myotubularin-related protein 10;
DE   AltName: Full=Inactive phosphatidylinositol 3-phosphatase 10 {ECO:0000305};
GN   Name=Mtmr10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127.
RX   PubMed=14691545; DOI=10.1371/journal.pbio.0000074;
RA   Sharov A.A., Piao Y., Matoba R., Dudekula D.B., Qian Y., VanBuren V.,
RA   Falco G., Martin P.R., Stagg C.A., Bassey U.C., Wang Y., Carter M.G.,
RA   Hamatani T., Aiba K., Akutsu H., Sharova L., Tanaka T.S., Kimber W.L.,
RA   Yoshikawa T., Jaradat S.A., Pantano S., Nagaraja R., Boheler K.R., Taub D.,
RA   Hodes R.J., Longo D.L., Schlessinger D., Keller J., Klotz E., Kelsoe G.,
RA   Umezawa A., Vescovi A.L., Rossant J., Kunath T., Hogan B.L.M., Curci A.,
RA   D'Urso M., Kelso J., Hide W., Ko M.S.H.;
RT   "Transcriptome analysis of mouse stem cells and early embryos.";
RL   PLoS Biol. 1:410-419(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-771.
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Egg, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000305}.
CC   -!- CAUTION: Although it belongs to the non-receptor class myotubularin
CC       subfamily, lacks the conserved active site cysteine residue at position
CC       399 in the dsPTPase catalytic loop, suggesting that it has no
CC       phosphatase activity. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH55074.1; Type=Miscellaneous discrepancy; Note=Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR   EMBL; CN669724; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC055074; AAH55074.1; ALT_SEQ; mRNA.
DR   EMBL; BC058196; AAH58196.1; -; mRNA.
DR   CCDS; CCDS39976.1; -.
DR   RefSeq; NP_766330.2; NM_172742.2.
DR   AlphaFoldDB; Q7TPM9; -.
DR   SMR; Q7TPM9; -.
DR   BioGRID; 231402; 1.
DR   STRING; 10090.ENSMUSP00000032736; -.
DR   iPTMnet; Q7TPM9; -.
DR   PhosphoSitePlus; Q7TPM9; -.
DR   jPOST; Q7TPM9; -.
DR   MaxQB; Q7TPM9; -.
DR   PaxDb; Q7TPM9; -.
DR   PeptideAtlas; Q7TPM9; -.
DR   PRIDE; Q7TPM9; -.
DR   ProteomicsDB; 291456; -.
DR   Antibodypedia; 65234; 34 antibodies from 13 providers.
DR   DNASU; 233315; -.
DR   Ensembl; ENSMUST00000032736; ENSMUSP00000032736; ENSMUSG00000030522.
DR   GeneID; 233315; -.
DR   KEGG; mmu:233315; -.
DR   UCSC; uc009hgd.1; mouse.
DR   CTD; 54893; -.
DR   MGI; MGI:2142292; Mtmr10.
DR   VEuPathDB; HostDB:ENSMUSG00000030522; -.
DR   eggNOG; KOG1089; Eukaryota.
DR   GeneTree; ENSGT00940000156900; -.
DR   HOGENOM; CLU_021912_1_0_1; -.
DR   InParanoid; Q7TPM9; -.
DR   OMA; DKMFFSN; -.
DR   OrthoDB; 620702at2759; -.
DR   PhylomeDB; Q7TPM9; -.
DR   TreeFam; TF315197; -.
DR   BioGRID-ORCS; 233315; 4 hits in 73 CRISPR screens.
DR   ChiTaRS; Mtmr10; mouse.
DR   PRO; PR:Q7TPM9; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q7TPM9; protein.
DR   Bgee; ENSMUSG00000030522; Expressed in vestibular membrane of cochlear duct and 260 other tissues.
DR   ExpressionAtlas; Q7TPM9; baseline and differential.
DR   Genevisible; Q7TPM9; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR   CDD; cd13346; PH-GRAM_MTMR10; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR030573; MTMR10.
DR   InterPro; IPR036004; MTMR10_PH-GRAM.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; PTHR10807; 1.
DR   PANTHER; PTHR10807:SF39; PTHR10807:SF39; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 2.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..771
FT                   /note="Myotubularin-related protein 10"
FT                   /id="PRO_0000284361"
FT   DOMAIN          217..657
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00669"
FT   MOD_RES         603
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXD2"
FT   MOD_RES         745
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXD2"
SQ   SEQUENCE   771 AA;  88197 MW;  26FD2B5CE5BCB0E8 CRC64;
     MFSLKPPRPS FRSYLLPPAQ TDDKISSEPK IKKLEPVLLP GEIVVNEVNF VRKCIATDTS
     QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV PLTCIEQIVT VNDHKRKQKV
     LGPNQKLKFN PTELIIYCKD FRIVRFRFDE SGPESAKKVC LAIAHYSQPT DLQLLFAFEY
     VGKKYHNSAN KVNGVSSGGG GVWSGAGSTG SQRTPLFETY SDWDRETKRT GASGWRVCSI
     NEGYMISTCL PEYFVVPSSL ADQDLKIFSH SFVGRRMPFW CWSHSNGSAL VRMALIKDAL
     QQRKIDQRIC NAITKSHPQR SDVYKSDLDK ALPNIQEIQA AFVKLKQLCV NEPFEETEEK
     WLSSLESTRW LEYVRAFLKH SAELVYILES QRLSVVLQEE EGRDLSCLVA SLIQVMMDPY
     FRTITGFQSL IQKEWVMAGY QFLDRCNHLK RSEKESPLFL LFLDTTWQLL EQYPAAFEFS
     ETYLAVLCDS TRISLFGTFL FNSPHQRVKQ STEFAISKNI QLGDEKGLKF PSVWDWALQF
     TAKDRTLFHN PFYIGKSTPC VQNGSRKSFK RTKKSYSSTL RGMPSCLKNG IITDQDLLPR
     RNSLVLKLKP DPPQHTDSQH SGAEQYFKEW FSRPANLHGI ILPRLSGTHI KLWKLCYFRW
     VPEAQINLGG SIMAFHKLSL LADEVDMLSR MLRQHRSGPL EACYAELDQS RMYFRATGPH
     DTLGTPEFLS SSFPFSPVGN LCRRSILGTP LSKFLSGAKI WLSTETLANE D