MTMRB_MOUSE
ID MTMRB_MOUSE Reviewed; 700 AA.
AC Q3V1L6; Q80UV0; Q8CG88;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Myotubularin-related protein 11;
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 11 {ECO:0000305};
GN Name=Mtmr11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000305}.
CC -!- CAUTION: Although it belongs to the non-receptor class myotubularin
CC subfamily, lacks the conserved active site cysteine residue at position
CC 380 in the dsPTPase catalytic loop, suggesting that it has no
CC phosphatase activity. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH51083.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK132375; BAE21134.1; -; mRNA.
DR EMBL; BC042764; AAH42764.1; -; mRNA.
DR EMBL; BC051083; AAH51083.1; ALT_INIT; mRNA.
DR CCDS; CCDS51000.1; -.
DR RefSeq; NP_852074.2; NM_181409.3.
DR AlphaFoldDB; Q3V1L6; -.
DR SMR; Q3V1L6; -.
DR STRING; 10090.ENSMUSP00000062341; -.
DR iPTMnet; Q3V1L6; -.
DR PhosphoSitePlus; Q3V1L6; -.
DR MaxQB; Q3V1L6; -.
DR PaxDb; Q3V1L6; -.
DR PRIDE; Q3V1L6; -.
DR ProteomicsDB; 286079; -.
DR Antibodypedia; 34015; 52 antibodies from 13 providers.
DR DNASU; 194126; -.
DR Ensembl; ENSMUST00000054356; ENSMUSP00000062341; ENSMUSG00000045934.
DR GeneID; 194126; -.
DR KEGG; mmu:194126; -.
DR UCSC; uc008qmd.2; mouse.
DR CTD; 10903; -.
DR MGI; MGI:2652817; Mtmr11.
DR VEuPathDB; HostDB:ENSMUSG00000045934; -.
DR eggNOG; KOG4471; Eukaryota.
DR GeneTree; ENSGT00940000160276; -.
DR HOGENOM; CLU_021912_1_0_1; -.
DR InParanoid; Q3V1L6; -.
DR OMA; YTPEYSQ; -.
DR OrthoDB; 620702at2759; -.
DR PhylomeDB; Q3V1L6; -.
DR TreeFam; TF315197; -.
DR BioGRID-ORCS; 194126; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Mtmr11; mouse.
DR PRO; PR:Q3V1L6; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q3V1L6; protein.
DR Bgee; ENSMUSG00000045934; Expressed in metanephric proximal tubule and 134 other tissues.
DR ExpressionAtlas; Q3V1L6; baseline and differential.
DR Genevisible; Q3V1L6; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IBA:GO_Central.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR InterPro; IPR030580; MTMR11.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; PTHR10807; 1.
DR PANTHER; PTHR10807:SF51; PTHR10807:SF51; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 2.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..700
FT /note="Myotubularin-related protein 11"
FT /id="PRO_0000337099"
FT DOMAIN 201..644
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00669"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 78396 MW; 53E823B9DE9BB966 CRC64;
MWWGGRGQSF NIAPQKEEPE MGLSGPKSNP GNRMPEPSSH QLGSCLASGC LPGEHILAWA
PGRRKGPGLD LPGTLICTNF RVTFQPCGWQ RKQDTPLSSE NDFALINIGR LEAVSGLSRV
QLLRPGSQLK FIPEELLLHG RDFRLLRVGF EAGGLAPQAF QVTMAIIQAR AQSSQVQQYR
GITLSKVGKV SGSRKPPIPL LETLEDWETE CKKQGARGWR VSTVNERFDV ATSLSGYFWV
PNRILDSEVR RAFAHFHQGR GPRLSWHHPG GSDLLRCGGF YIASDPNKED IRAVESMLQA
GHSDVVLVET MDEMPSLADI QLAHLKLRAL CLPDSSVAED KWLSALEGTR WLDYVRSCLR
KASDISVLVT SRVRSVVLQE LGDRDFNGLL SSLVQLLLAP EARTLFGFQS LVQREWVAAG
HPFLTRLGDT GASEEAPVFP LFLDCAWQLL QQFPAEFEFS EFFLLALHDS IRVPDTLTFL
RNTPWERGKK SGQFNSYTQV YTPEYSQPLA GSSANLHLSV WDWDLRYSKE QISQFLNPGY
DPEHCPDSRF SRQQQSLMVP GPPSSMWLFS RGTLTPLNQL CPWQDSSSLL AVSSHWLPRP
ARSSESLADQ EWGLPSHWGA CPLPPGLLLP GYLGPQIRFW KRCYLRGRPE VQMGSSALTV
SALQDELSHL QELLRQWTPR ISPEDQSKKR DPNTILSQIC