MTMRD_XENLA
ID MTMRD_XENLA Reviewed; 1873 AA.
AC Q6NTN5;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Myotubularin-related protein 13;
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 13 {ECO:0000305};
DE AltName: Full=SET-binding factor 2;
GN Name=sbf2; Synonyms=mtmr13;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate
CC Rab small GTPases (By similarity). Promotes the exchange of GDP to GTP,
CC converting inactive GDP-bound Rab proteins into their active GTP-bound
CC form (By similarity). Acts as an adapter for the phosphatase mtmr2 (By
CC similarity). {ECO:0000250|UniProtKB:E9PXF8,
CC ECO:0000250|UniProtKB:Q86WG5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86WG5}.
CC Membrane {ECO:0000250|UniProtKB:Q86WG5}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q86WG5}. Note=Associated with membranes.
CC {ECO:0000250|UniProtKB:Q86WG5}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000305}.
CC -!- CAUTION: Although it belongs to the non-receptor class myotubularin
CC subfamily, lacks the conserved active site cysteine residue at position
CC 1439 in the dsPTPase catalytic loop, suggesting that it has no
CC phosphatase activity. {ECO:0000305}.
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DR EMBL; BC068924; AAH68924.1; -; mRNA.
DR RefSeq; NP_001084507.1; NM_001091038.1.
DR AlphaFoldDB; Q6NTN5; -.
DR SMR; Q6NTN5; -.
DR MaxQB; Q6NTN5; -.
DR PRIDE; Q6NTN5; -.
DR DNASU; 414452; -.
DR GeneID; 414452; -.
DR KEGG; xla:414452; -.
DR CTD; 414452; -.
DR Xenbase; XB-GENE-1004473; sbf2.L.
DR OrthoDB; 45015at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 414452; Expressed in egg cell and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0019208; F:phosphatase regulator activity; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0043087; P:regulation of GTPase activity; IEA:InterPro.
DR CDD; cd13339; PH-GRAM_MTMR13; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR030567; MTMR13.
DR InterPro; IPR037823; MTMR13_PH-GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; PTHR10807; 1.
DR PANTHER; PTHR10807:SF4; PTHR10807:SF4; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW Reference proteome.
FT CHAIN 1..1873
FT /note="Myotubularin-related protein 13"
FT /id="PRO_0000094946"
FT DOMAIN 7..171
FT /note="uDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 190..323
FT /note="cDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 325..426
FT /note="dDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 869..955
FT /note="GRAM"
FT /evidence="ECO:0000255"
FT DOMAIN 1105..1613
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00669"
FT DOMAIN 1767..1871
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 1064..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1080
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1873 AA; 210866 MW; 46D9D716D1716FDA CRC64;
MARLADYFIV VGYDHEKTGS EGFGKIIQRF PMTDWSDTPF PQGIELFCQP GGWQLSRERK
QPTFFIVVLT DIDSDRHYCA CLTFYEAEIN LQGTKREHSE TEEEDSGLIQ PAQVFAPKSL
VLVSRLDYPE IFRACLGLIY TVYIDSLNVS LENLVSNLVT CIVPCAGGSQ KLFSLGAGDR
QLIQTPLHDS LPVTGTSVAL LFQQLGIQNV LSLFCAVLTE NKVLFHSSSF QRLGDACRAL
EALIYPLKYS YPYIPILPAQ LLEVLSSPTP FIIGVHSVFC SEIHDLLDVI IADLDGGTIK
IPECIHLSPI PEPLLHQTQA ALSLVLHPDL EVADNAFAPL RTPVPHIKLL DKEVRAVFLR
LFAQIFQGYR SCLQLIRIHA EPIIHFHKAA FLGQRGLIEN DFLTKVLSGM SFAGFVSERG
PPYRPCDLFD ELVSFEVERI KDDDQNDTHK ILKHIRELAE QLFKNENPNP HMAFQKVPKP
TEGSHLRVHI LPFSKMNDLK VQELIQEGLN KNQNSILSPR AEKKCVVPAG SPVVSIVDKA
SSVFNSARRL EVVRNCIMYI FENKTLETEK TLPAALRALK GKAARQCLTE ELALHVQQNR
SMLNHQQFDY IVRMMNCALQ DCSGSEEYTI ASQLLPLATA FCRKLSAAVS QFAYTCVQDH
GVWANQQFWE TTFYNDVQNQ VRSLYLTTKN GNQGASEPKE NGVDSGNPER TVMDLAAEQL
RLWPTLSKET QQELIQSEES TVFSQAIHFA NLMVYLLVPL DTSKNKLLRT SATGDWESGS
NSIVTNSIAG SVAESYDTES GFEDSENDIA NSVVRFITRF IDKVCTESGV TQDHIKSLHC
MIPGIVAMHI ETLEAVHRES RRLPPIKKPK IMRPALLPGE EFVCEALRVL LDPDGREEAT
GGMLGGPHIL PAEGALFLTT YRIIFKGTPH DALVGEQTVI RSVPIASITR EKKINVQNQL
HQNMQEGLQI RSATFQLIKV AFDEEVSAEM VDLFKKQLMK FRYPLSIFSA FAFAAGQTAP
PIILPKQKEK NTSFRTISKT IVKGAKRAGK MTIGRQYAAK KKTGTILEER GSRSGGNEDD
DISVSDDNEL PSGTLKPSEK STMEQLVERA CFRDYQRLAL GTISNSSTRF KSEHFRVTAL
NRMHSLCRSY PGLLVVPQSV QDSSLQKVAR CYRHNRLPVV SWKNAKTNAV LLRGGGFHGK
TVVGLFKSQN THTAAPASSL ESSSSIEQEK YLQALLNAIS VHYKMNGNST LTVRPTLALS
PGSDRKSSRM SSVVKHVVPS HVDGSLSHSF ARGGVWASLR SSNRLITTQT PLIDVGARLV
GKDLQTTYTD HSALQSQLLK RQAALYIFGE KSQLRGFKFD FALNCEFVPV EFGDIRQVKT
SFKKLMRACV PSSNPTDSES TFLKAMGESE WFLQIHRIIQ LSVIISELME SGSSVMICLE
DGWDITTQVV SLVQILGDPF YRTLEGFRML IEKEWLSFGH KFSQRSNLSP SSQGTGFVPI
FLQFLDCVHQ IHNQYPTEFE FNRYYLKFLA YHHVSNRFKT FLLDSDYERL EHGTLFEDKG
DKHSRRGICI WEYIERIHKK KTVFFNYLFA PTELEALKPS ANISTLRKWE YYMEETLASG
PSYDWIITPS RFNASDETDS GEEAQQQGKR KIVWPCYDDV QKVQPDAITH LMNEIERLEI
KLNQTSERWQ LLWERAKVKL KENAKKENNN PASLVSANLQ SYQKRSMVHL PDSGLGDEQN
LNASPSNGVD RRTATLYNHF TSKNEENRSY EGILYKRGAL LKGWKPRWFV LDITKHQLRY
YDSGEDTSCK GYIDLADVET VVPAAPTIGA PKHANEKAFF DVKTSKRVYN FCAQDAQSAQ
LWMDKIQNCI SDA
