ID   MTNA_DANRE              Reviewed;         353 AA.
AC   A9JRE2;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119};
DE            Short=M1Pi {ECO:0000255|HAMAP-Rule:MF_03119};
DE            Short=MTR-1-P isomerase {ECO:0000255|HAMAP-Rule:MF_03119};
DE            EC=5.3.1.23 {ECO:0000255|HAMAP-Rule:MF_03119};
DE   AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119};
DE   AltName: Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein {ECO:0000255|HAMAP-Rule:MF_03119};
GN   Name=mri1; ORFNames=zgc:172216;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-phosphate
CC       (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
CC       {ECO:0000255|HAMAP-Rule:MF_03119}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-
CC         D-ribulose 1-phosphate; Xref=Rhea:RHEA:19989, ChEBI:CHEBI:58533,
CC         ChEBI:CHEBI:58548; EC=5.3.1.23; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_03119};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage
CC       pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate:
CC       step 1/6. {ECO:0000255|HAMAP-Rule:MF_03119}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03119}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03119}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       MtnA subfamily. {ECO:0000255|HAMAP-Rule:MF_03119}.
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DR   EMBL; BC155626; AAI55627.1; -; mRNA.
DR   EMBL; BC171374; AAI71374.1; -; mRNA.
DR   EMBL; BC171376; AAI71376.1; -; mRNA.
DR   RefSeq; NP_001104708.1; NM_001111238.1.
DR   AlphaFoldDB; A9JRE2; -.
DR   SMR; A9JRE2; -.
DR   STRING; 7955.ENSDARP00000098757; -.
DR   PaxDb; A9JRE2; -.
DR   PeptideAtlas; A9JRE2; -.
DR   PRIDE; A9JRE2; -.
DR   Ensembl; ENSDART00000111671; ENSDARP00000098757; ENSDARG00000075754.
DR   GeneID; 100002302; -.
DR   KEGG; dre:100002302; -.
DR   CTD; 84245; -.
DR   ZFIN; ZDB-GENE-080204-109; mri1.
DR   eggNOG; KOG1468; Eukaryota.
DR   GeneTree; ENSGT00390000013732; -.
DR   HOGENOM; CLU_016218_1_3_1; -.
DR   InParanoid; A9JRE2; -.
DR   OMA; RLWVDET; -.
DR   OrthoDB; 1410886at2759; -.
DR   PhylomeDB; A9JRE2; -.
DR   TreeFam; TF300852; -.
DR   Reactome; R-DRE-1237112; Methionine salvage pathway.
DR   UniPathway; UPA00904; UER00874.
DR   PRO; PR:A9JRE2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000075754; Expressed in retina and 20 other tissues.
DR   ExpressionAtlas; A9JRE2; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IBA:GO_Central.
DR   GO; GO:0019509; P:L-methionine salvage from methylthioadenosine; IBA:GO_Central.
DR   GO; GO:0019284; P:L-methionine salvage from S-adenosylmethionine; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.120.420; -; 1.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   HAMAP; MF_01678; Salvage_MtnA; 1.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-M1Pi.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   InterPro; IPR027363; M1Pi_N.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR00524; eIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; salvage_mtnA; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Cytoplasm; Isomerase; Methionine biosynthesis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..353
FT                   /note="Methylthioribose-1-phosphate isomerase"
FT                   /id="PRO_0000401971"
FT   ACT_SITE        241
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03119"
FT   SITE            161
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03119"
SQ   SEQUENCE   353 AA;  37980 MW;  DE2CF09DC849F475 CRC64;
     MTLEAIRYRS GSLQILNQLL LPRETVYDEI RSVRDGYEAI KSMKVRGAPA IAIVGCLSLA
     VELRAGAGAE DLVSFVRDSL CHLTSARPTA VNMGRAAREL MEFTENESME KNTEQLRDSV
     IGWIEEMLER DVNDNKKIGN YGAQHILSGV PRDSVTILTH CNTGSLATAG YGTALGVVRS
     LHMLGRLKRL YCTETRPYNQ GARLTAYEAV AEGFPATLIT DSMAALAMRE KSITAVVVGA
     DRVVANGDTA NKVGTYQLAI AAKHHGIPFY VAAPSTSCDL SLESGRDIVI EERPAEELTS
     INGVPVAAPG IDVWNPAFDV TPHQLITGGI ITELGVFLPS ELQAALTGRL TAL