MTP6_ORYSJ
ID MTP6_ORYSJ Reviewed; 376 AA.
AC Q0DHJ5; A0A0P0WN91; Q6L4Z8;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Metal tolerance protein 6;
DE Short=OsMTP6;
GN Name=MTP6; OrderedLocusNames=Os05g0461900, LOC_Os05g38670;
GN ORFNames=OJ1281_H05.16, OJ1525_A02.3;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT "A fine physical map of the rice chromosome 5.";
RL Mol. Genet. Genomics 274:337-345(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
CC -!- FUNCTION: Involved in sequestration of excess metal in the cytoplasm
CC into vacuoles to maintain metal homeostasis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Tonoplast.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT39176.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAT39183.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC108876; AAT39183.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC117265; AAT39176.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008211; BAF17678.2; -; Genomic_DNA.
DR EMBL; AP014961; BAS94416.1; -; Genomic_DNA.
DR RefSeq; XP_015638176.1; XM_015782690.1.
DR AlphaFoldDB; Q0DHJ5; -.
DR STRING; 4530.OS05T0461900-00; -.
DR PRIDE; Q0DHJ5; -.
DR EnsemblPlants; Os05t0461900-00; Os05t0461900-00; Os05g0461900.
DR Gramene; Os05t0461900-00; Os05t0461900-00; Os05g0461900.
DR KEGG; osa:4339024; -.
DR eggNOG; KOG1485; Eukaryota.
DR HOGENOM; CLU_013430_2_3_1; -.
DR InParanoid; Q0DHJ5; -.
DR OMA; WFTAFSK; -.
DR OrthoDB; 874665at2759; -.
DR Proteomes; UP000000763; Chromosome 5.
DR Proteomes; UP000059680; Chromosome 5.
DR Genevisible; Q0DHJ5; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0010486; F:manganese:proton antiporter activity; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; -; 1.
DR Gene3D; 3.30.70.1350; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027470; Cation_efflux_CTD.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR Pfam; PF01545; Cation_efflux; 1.
DR Pfam; PF16916; ZT_dimer; 1.
DR SUPFAM; SSF160240; SSF160240; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..376
FT /note="Metal tolerance protein 6"
FT /id="PRO_0000400014"
FT TOPO_DOM 1..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..149
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..191
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..231
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..376
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 41907 MW; E2C7538F2C39615C CRC64;
MAAAAGVAAG TGRGSGEGEE LLPNAVEGDG GCGGGGTCAG DRPWRLNFDG LRRPEAHQEK
PPRRFHDRLG GLVQSPGDDV AEYYQQQSEL LEGFNEMDTL TDRGFLPGMS KEECEKVARS
EALAIRLSNI ANMVLFAAKV YASIRSGSLA IIASTLDSLL DLLSGFILWF TAFSKKTSNP
YRYPIGKRRM QPLGILVFAS VMATLGLQII LESTRSLFYD GDTFRLTKEQ EKWVVDIMLS
VTSVKLLLVV YCRSFTNEIL AIYTIRTWSM TVLENVHSLV GQSASPEYLQ KLTYLCWNHH
KAVRHIDTVR AYTFGSHYFV EVDIVLPCDM PLQEAHDIGE APQEKLESLP EIERAFVHLD
YEFTHQPEHA RSHDTL
