位置:首页 > 蛋白库 > MTPN_CHICK
MTPN_CHICK
ID   MTPN_CHICK              Reviewed;         118 AA.
AC   Q91955; Q5ZHL6;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Myotrophin;
DE   AltName: Full=Granule cell differentiation protein;
DE   AltName: Full=Protein V-1;
GN   Name=MTPN; ORFNames=RCJMB04_23o21, RCJMB04_35l16;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens fibers;
RX   PubMed=8840185;
RA   Sawada K., Agata K., Eguchi G.;
RT   "Characterization of terminally differentiated cell state by categorizing
RT   cDNA clones derived from chicken lens fibers.";
RL   Int. J. Dev. Biol. 40:531-535(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Regulates NF-kappa-B transcription factor activity. Promotes
CC       growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes
CC       cardiac muscle hypertrophy. Plays a role in the regulation of the
CC       growth of actin filaments. Inhibits the activity of the F-actin-capping
CC       protein complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myotrophin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D26326; BAA05379.1; -; mRNA.
DR   EMBL; AJ720711; CAG32370.1; -; mRNA.
DR   EMBL; AJ721118; CAG32777.1; -; mRNA.
DR   RefSeq; NP_990217.1; NM_204886.2.
DR   AlphaFoldDB; Q91955; -.
DR   SMR; Q91955; -.
DR   STRING; 9031.ENSGALP00000042167; -.
DR   PaxDb; Q91955; -.
DR   Ensembl; ENSGALT00000059596; ENSGALP00000056408; ENSGALG00000041619.
DR   GeneID; 395702; -.
DR   KEGG; gga:395702; -.
DR   CTD; 136319; -.
DR   VEuPathDB; HostDB:geneid_395702; -.
DR   eggNOG; KOG4214; Eukaryota.
DR   GeneTree; ENSGT00430000031071; -.
DR   InParanoid; Q91955; -.
DR   OMA; TALIDCT; -.
DR   OrthoDB; 1435166at2759; -.
DR   PhylomeDB; Q91955; -.
DR   PRO; PR:Q91955; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000041619; Expressed in spleen and 13 other tissues.
DR   GO; GO:0030424; C:axon; ISS:AgBase.
DR   GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.
DR   GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
DR   GO; GO:0010557; P:positive regulation of macromolecule biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0051247; P:positive regulation of protein metabolic process; ISS:UniProtKB.
DR   GO; GO:2000812; P:regulation of barbed-end actin filament capping; ISS:UniProtKB.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..118
FT                   /note="Myotrophin"
FT                   /id="PRO_0000067034"
FT   REPEAT          1..30
FT                   /note="ANK 1"
FT   REPEAT          34..65
FT                   /note="ANK 2"
FT   REPEAT          67..98
FT                   /note="ANK 3"
SQ   SEQUENCE   118 AA;  12886 MW;  6097EB55C6CBD2CF CRC64;
     MSDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD
     INAPDKHNIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTAFEATDN QAIKTLLQ
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024