ID   MTPN_DANRE              Reviewed;         118 AA.
AC   Q7T2B9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Myotrophin;
GN   Name=mtpn;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye, and Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates NF-kappa-B transcription factor activity. Promotes
CC       growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes
CC       cardiac muscle hypertrophy. Plays a role in the regulation of the
CC       growth of actin filaments. Inhibits the activity of the F-actin-capping
CC       protein complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myotrophin family. {ECO:0000305}.
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DR   EMBL; BC054609; AAH54609.1; -; mRNA.
DR   EMBL; BC154009; AAI54010.1; -; mRNA.
DR   EMBL; BC155200; AAI55201.1; -; mRNA.
DR   RefSeq; NP_998137.1; NM_212972.2.
DR   AlphaFoldDB; Q7T2B9; -.
DR   SMR; Q7T2B9; -.
DR   STRING; 7955.ENSDARP00000072408; -.
DR   PaxDb; Q7T2B9; -.
DR   PRIDE; Q7T2B9; -.
DR   Ensembl; ENSDART00000172320; ENSDARP00000141690; ENSDARG00000104018.
DR   GeneID; 406240; -.
DR   KEGG; dre:406240; -.
DR   CTD; 136319; -.
DR   ZFIN; ZDB-GENE-040426-2166; mtpn.
DR   eggNOG; KOG4214; Eukaryota.
DR   GeneTree; ENSGT00430000031071; -.
DR   HOGENOM; CLU_000134_45_7_1; -.
DR   InParanoid; Q7T2B9; -.
DR   OMA; TALIDCT; -.
DR   OrthoDB; 1435166at2759; -.
DR   PhylomeDB; Q7T2B9; -.
DR   TreeFam; TF327387; -.
DR   PRO; PR:Q7T2B9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 4.
DR   Bgee; ENSDARG00000104018; Expressed in pharyngeal gill and 27 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:2000812; P:regulation of barbed-end actin filament capping; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..118
FT                   /note="Myotrophin"
FT                   /id="PRO_0000330661"
FT   REPEAT          1..30
FT                   /note="ANK 1"
FT   REPEAT          34..65
FT                   /note="ANK 2"
FT   REPEAT          67..98
FT                   /note="ANK 3"
SQ   SEQUENCE   118 AA;  12749 MW;  AE51FFECF90388F4 CRC64;
     MGDKELMWAL KNGDLDEVKN ILVKAEDVNR TLEGGRKPLH YAADCGQAEM LEFLLSKGAD
     VNAPDKHGIT PLLSATYEGH VTCVKILLEK GADKNRKGPD GLSAFEAAES EAIKALLE