ID   MTPN_DICDI              Reviewed;         120 AA.
AC   Q55FM5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Myotrophin homolog;
GN   Name=mtpn; ORFNames=DDB_G0268038;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May regulate NF-kappa-B transcription factor activity. Plays
CC       a role in the regulation of the growth of actin filaments. Inhibits the
CC       activity of the F-actin-capping protein complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myotrophin family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73472.1; -; Genomic_DNA.
DR   RefSeq; XP_647508.1; XM_642416.1.
DR   AlphaFoldDB; Q55FM5; -.
DR   SMR; Q55FM5; -.
DR   STRING; 44689.DDB0305263; -.
DR   PaxDb; Q55FM5; -.
DR   EnsemblProtists; EAL73472; EAL73472; DDB_G0268038.
DR   GeneID; 8616315; -.
DR   KEGG; ddi:DDB_G0268038; -.
DR   dictyBase; DDB_G0268038; mtpn.
DR   eggNOG; KOG4214; Eukaryota.
DR   HOGENOM; CLU_000134_45_7_1; -.
DR   InParanoid; Q55FM5; -.
DR   OMA; TALIDCT; -.
DR   PhylomeDB; Q55FM5; -.
DR   PRO; PR:Q55FM5; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0044877; F:protein-containing complex binding; IDA:dictyBase.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IMP:dictyBase.
DR   GO; GO:2000813; P:negative regulation of barbed-end actin filament capping; IDA:dictyBase.
DR   GO; GO:2000812; P:regulation of barbed-end actin filament capping; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF13637; Ank_4; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..120
FT                   /note="Myotrophin homolog"
FT                   /id="PRO_0000330660"
FT   REPEAT          1..31
FT                   /note="ANK 1"
FT   REPEAT          36..65
FT                   /note="ANK 2"
FT   REPEAT          69..98
FT                   /note="ANK 3"
SQ   SEQUENCE   120 AA;  12998 MW;  050C0FAD43785C22 CRC64;
     MEEQNDFTWA VKNGDIANVK KSVEAKKDLI SITDGNKRGP CHWAADFNQV EVLEYLISKG
     AKFDNTDDYG ITPLLAAVYE GHTGAVELLV KKGANKSVVG PDGQTAYDAA EKADIKALLK